{"id":"W4322012021","doi":"10.1016/j.esmoop.2023.100830","title":"50P Can we learn from failures? A systematic review and metanalysis of phase III trials in platinum resistant ovarian cancer","year":2023,"lang":"en","type":"review","venue":"ESMO Open","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Randomized controlled trial; Ovarian cancer; Internal medicine; Oncology; Population; Biomarker; Chemotherapy; Clinical trial; Meta-analysis; Progression-free survival; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004212928,0.0006045995,0.017417,0.0003910687,0.00005551175,0.0001047557,0.0004673226,0.0002453919,0.001399351],"category_scores_gemma":[0.001397542,0.0003808998,0.0008490367,0.001153947,0.0000471369,0.00007339063,0.0002666278,0.0003460114,0.00002770076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005059883,"about_ca_system_score_gemma":0.001125254,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.06417259,"about_ca_topic_score_gemma":0.02503643,"domain_scores_codex":[0.9929269,0.001830691,0.003658521,0.0008371916,0.0004415075,0.0003052168],"domain_scores_gemma":[0.9943094,0.001691057,0.002563627,0.001131417,0.00009472804,0.0002098312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001140548,0.0002991856,0.00001010171,0.9204004,0.01576568,0.0003278192,0.0001969744,2.149276e-7,2.214533e-7,0.0001460976,0.00234959,0.0603896],"study_design_scores_gemma":[0.004501345,0.000148739,0.00001118434,0.7186543,0.1133573,0.000007014971,0.000057432,0.000001889594,0.000001233705,0.00004860722,0.1629429,0.000268044],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003225049,0.9823906,0.000001917399,0.002966495,0.00009428487,0.01258039,0.00166785,0.00001854213,0.0002766923],"genre_scores_gemma":[0.00004497893,0.9911455,0.0002175997,0.0001742174,0.00009392695,0.005836802,0.0005957592,0.00009099921,0.00180025],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2017461,"threshold_uncertainty_score":0.9998643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1868341639535957,"score_gpt":0.4573465076282759,"score_spread":0.2705123436746802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}