{"id":"W4322102272","doi":"10.1016/j.labinv.2023.100123","title":"Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration Through Proteolysis of Thrombospondin-1","year":2023,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Macular degeneration; Choroidal neovascularization; Retinal pigment epithelium; Choroid; Angiogenesis; Retinal; Retina; Medicine; Biology; Cancer research; Ophthalmology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067956,0.0003967601,0.0002192528,0.0003172093,0.0001435279,0.000314608,0.0001641587,0.0003772712,0.00115791],"category_scores_gemma":[0.0002682935,0.0001470183,0.0003513723,0.0001651637,0.000217369,0.0002615257,0.0002574619,0.0003993737,0.0002749822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002207589,"about_ca_system_score_gemma":0.000165664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004284232,"about_ca_topic_score_gemma":0.0002720584,"domain_scores_codex":[0.9998701,0.00003593148,0.00001483223,0.00002617611,0.00003246037,0.00002055341],"domain_scores_gemma":[0.9999028,0.00001199315,0.00004275941,0.00001028071,0.00001400504,0.00001807473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001035535,0.0001850007,0.004512794,0.0002751588,0.00007650947,0.0009101227,0.00007196851,0.0003731496,0.9798768,0.0004098647,0.0002375993,0.01203543],"study_design_scores_gemma":[0.0003666207,0.002017574,0.1080855,0.00007801688,0.0002474862,0.008307124,0.0003040041,0.007829215,0.8493834,0.001931881,0.02141177,0.00003745834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977812,0.01732848,0.002659705,0.0002237662,0.00004805755,0.00006227644,0.0001538786,0.00005030877,0.001661491],"genre_scores_gemma":[0.9919187,0.004210657,0.001370676,0.00008846233,0.00001533169,0.00003232325,0.0001763723,0.000009117712,0.002178268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00115791,"threshold_uncertainty_score":0.003873587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196806205566817,"score_gpt":0.2476315504639165,"score_spread":0.2356634884082483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}