{"id":"W4322153997","doi":"10.1016/j.omtm.2023.02.013","title":"Packaging cells for lentiviral vectors generated using the cumate and coumermycin gene induction systems and nanowell single-cell cloning","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Cloning (programming); Computational biology; Biology; Viral vector; Cell biology; Gene; Genetics; Computer science; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009116256,0.0006966973,0.0006475365,0.000689906,0.000464588,0.0008343835,0.000863579,0.0007482443,0.00261311],"category_scores_gemma":[0.0005597325,0.0004775524,0.0005006553,0.000664414,0.0003747354,0.0004603566,0.0005123402,0.001599802,0.002353853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004287243,"about_ca_system_score_gemma":0.0004731987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003939205,"about_ca_topic_score_gemma":0.0007586798,"domain_scores_codex":[0.999231,0.0001035979,0.0001109432,0.0001448881,0.0003259009,0.00008369102],"domain_scores_gemma":[0.9996918,0.00006445415,0.00007585203,0.00006605353,0.00006406978,0.00003772428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004404657,0.00004849131,0.0001342248,0.00009837435,0.000008128851,0.00006630669,0.0000843457,0.00009604393,0.9904557,0.00137336,0.0004126676,0.007178364],"study_design_scores_gemma":[0.00002688422,0.0001745103,0.0005998536,0.00002058265,0.00003058989,0.0003329315,0.00002194406,0.001877216,0.9722563,0.0002284224,0.02441454,0.00001618419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2457463,0.00302466,0.7272472,0.0003212858,0.0005867327,0.004190317,0.004546853,0.002710132,0.01162641],"genre_scores_gemma":[0.3139774,0.003421965,0.6441121,0.0003081745,0.0001482162,0.003590307,0.01228725,0.0008883139,0.02126631],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00261311,"threshold_uncertainty_score":0.008741677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1438409571344634,"score_gpt":0.4290596482723057,"score_spread":0.2852186911378423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}