{"id":"W4322154777","doi":"10.1016/j.jhepr.2023.100715","title":"A genomic enhancer signature associates with hepatocellular carcinoma prognosis","year":2023,"lang":"en","type":"article","venue":"JHEP Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Medical Research Council; Medical Research Council","keywords":"Hepatocellular carcinoma; Enhancer; Signature (topology); Cancer research; Computational biology; Biology; Genetics; Gene; Gene expression; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868486,0.0001216588,0.0001851452,0.0003953122,0.000101467,0.0002099207,0.0001093576,0.0001648168,0.00190176],"category_scores_gemma":[0.0007325739,0.00005475194,0.0001610785,0.0003905748,0.0001355614,0.00009385887,0.0002043196,0.0001840915,0.0002218612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150004,"about_ca_system_score_gemma":0.00009671137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004468746,"about_ca_topic_score_gemma":0.0007312953,"domain_scores_codex":[0.9998971,0.0000211977,0.00001059159,0.00002994697,0.00002044166,0.00002072741],"domain_scores_gemma":[0.9993023,0.0001564067,0.0003086724,0.00005688196,0.00007884033,0.00009692885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007736242,0.00003485812,0.9523436,0.00003915729,0.0000879726,0.0001782087,0.00005207424,0.0003210715,0.03685177,0.000063088,0.0001661827,0.00908833],"study_design_scores_gemma":[0.000004596953,0.00008478785,0.9951125,0.000003828548,0.0000399181,0.0006220223,0.00004346159,0.0005864917,0.003130219,0.0001214715,0.000246044,0.000004818797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986743,0.0001598006,0.0003984608,0.00003338004,0.00000309218,0.000003485884,0.0004077647,0.00001684295,0.0003030441],"genre_scores_gemma":[0.9993326,0.00002510543,0.0001841282,0.000008473143,0.00000331431,0.000002550491,0.0003490384,0.000002657068,0.00009192192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00190176,"threshold_uncertainty_score":0.006361961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009057418960118191,"score_gpt":0.2293693131870307,"score_spread":0.2203118942269125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}