{"id":"W4322154777","doi":"10.1016/j.jhepr.2023.100715","title":"A genomic enhancer signature associates with hepatocellular carcinoma prognosis","year":2023,"lang":"en","type":"article","venue":"JHEP Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Medical Research Council; Medical Research Council","keywords":"Hepatocellular carcinoma; Enhancer; Signature (topology); Cancer research; Computational biology; Biology; Genetics; Gene; Gene expression; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002577078,0.0001456605,0.0001379575,0.00004951717,0.0000898357,0.0000319897,0.0000697636,0.0001796,0.00002013924],"category_scores_gemma":[0.0000514081,0.0001245507,0.00007649293,0.0001816267,0.00003162089,0.000002767065,0.00006798517,0.00008314041,0.00001371524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002127111,"about_ca_system_score_gemma":0.00009316491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003274811,"about_ca_topic_score_gemma":0.00002538962,"domain_scores_codex":[0.9989016,0.00003192492,0.0002218794,0.0004127017,0.0001762621,0.0002556025],"domain_scores_gemma":[0.9993244,0.000008666945,0.0001776727,0.0003157842,0.0001023429,0.0000711592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009921425,0.00001677517,0.4673838,0.000009734981,0.00003251782,0.0001241531,0.00003480163,0.00005537648,0.5313191,0.000002336234,0.0005455069,0.0004658836],"study_design_scores_gemma":[0.0001456736,0.0001903362,0.1997315,0.000009769811,0.00003011058,0.00001775503,0.00002476446,0.0001523595,0.7766553,0.0001745308,0.02264798,0.0002199241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996356,0.001917809,0.0001369518,0.00009426006,0.0001537238,0.0002737461,0.000006019408,0.00004298136,0.001018519],"genre_scores_gemma":[0.9970078,0.0001761873,0.0002749346,0.00003807314,0.0002277969,0.00008181387,0.0002988653,0.00003715937,0.001857399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2676524,"threshold_uncertainty_score":0.507903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009057418960118191,"score_gpt":0.2293693131870307,"score_spread":0.2203118942269125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}