{"id":"W4322207820","doi":"10.1101/2023.02.23.23286373","title":"Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; BC Mental Health & Substance Use Services; Health Sciences Centre; Sunnybrook Health Science Centre; Dalhousie University; BC Children's Hospital; University of Toronto; Hospital for Sick Children; University of British Columbia; University of Calgary","funders":"National Institute of Mental Health; Alberta Innovates; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Toronto; Substance Abuse and Mental Health Services Administration; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Department of Psychiatry, University of Toronto; Instituto D'Or de Pesquisa e Ensino; Patient-Centered Outcomes Research Institute; National Institutes of Health; National Science Foundation","keywords":"Latin Americans; Genetic genealogy; Genomics; Genome-wide association study; Polygenic risk score; Identification (biology); Medicine; Genetics; Biology; Single-nucleotide polymorphism; Genome; Population; Political science; Genotype; Environmental health; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01519098,0.002273514,0.002880617,0.002244481,0.005184258,0.00332303,0.003025222,0.00298214,0.104069],"category_scores_gemma":[0.01724102,0.002455727,0.002092205,0.002112127,0.001516329,0.002829735,0.002705195,0.004618367,0.02474932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004632197,"about_ca_system_score_gemma":0.01945047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01602629,"about_ca_topic_score_gemma":0.0245425,"domain_scores_codex":[0.994852,0.002489819,0.000880761,0.0008373678,0.0004301305,0.0005098815],"domain_scores_gemma":[0.9888366,0.002249781,0.00142559,0.001838471,0.00405988,0.001589604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05387923,0.01033467,0.02041936,0.02143309,0.0008654027,0.001862581,0.004844314,0.00231581,0.002323936,0.02015376,0.7232681,0.1382997],"study_design_scores_gemma":[0.06342076,0.007161316,0.06120242,0.02008432,0.0007601724,0.001136499,0.005725314,0.003159747,0.001929908,0.02911101,0.8057588,0.0005497033],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.004476374,0.0006876939,0.007094336,0.001416916,0.0004849081,0.9448032,0.03252923,0.0002843315,0.00822294],"genre_scores_gemma":[0.002838741,0.0002943665,0.004075201,0.0008086562,0.0000674554,0.9856389,0.004803989,0.00003144992,0.001441237],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.104069,"threshold_uncertainty_score":0.3481454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1017192658535194,"score_gpt":0.4076212459539127,"score_spread":0.3059019801003933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}