{"id":"W4322207820","doi":"10.1101/2023.02.23.23286373","title":"Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; BC Mental Health & Substance Use Services; Health Sciences Centre; Sunnybrook Health Science Centre; Dalhousie University; BC Children's Hospital; University of Toronto; Hospital for Sick Children; University of British Columbia; University of Calgary","funders":"National Institute of Mental Health; Alberta Innovates; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Toronto; Substance Abuse and Mental Health Services Administration; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Department of Psychiatry, University of Toronto; Instituto D'Or de Pesquisa e Ensino; Patient-Centered Outcomes Research Institute; National Institutes of Health; National Science Foundation","keywords":"Latin Americans; Genetic genealogy; Genomics; Genome-wide association study; Polygenic risk score; Identification (biology); Medicine; Genetics; Biology; Single-nucleotide polymorphism; Genome; Population; Political science; Genotype; Environmental health; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005570512,0.0007719764,0.001199138,0.0003550063,0.0001952146,0.00009448708,0.0011176,0.000324585,0.0004173685],"category_scores_gemma":[0.0001951805,0.0007912448,0.0004271798,0.0005070035,0.0003874617,0.00005151266,0.0003877993,0.001303792,0.0002859672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912333,"about_ca_system_score_gemma":0.0003069548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005568929,"about_ca_topic_score_gemma":0.0006817945,"domain_scores_codex":[0.995424,0.0005988205,0.001021131,0.001699959,0.0003958132,0.0008602979],"domain_scores_gemma":[0.9965087,0.0006764256,0.001099257,0.001352356,0.0001890085,0.0001742737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00110888,0.001953917,0.9369171,0.0004634621,0.001627634,0.0001638399,0.04351813,0.000704779,0.0001159074,0.0005594091,0.002271939,0.01059499],"study_design_scores_gemma":[0.004324739,0.001261828,0.9653125,0.00009464352,0.0002038187,0.000001347499,0.01774308,0.0002059093,0.0001007941,0.005555993,0.004179024,0.001016328],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.723447,0.00001539491,0.003960353,0.0009816863,0.00174658,0.2638951,0.0003486533,0.0005634475,0.005041788],"genre_scores_gemma":[0.5033327,0.000002312329,0.001669555,0.0001931254,0.0005069892,0.4928052,0.00008001804,0.0002687532,0.001141279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2289101,"threshold_uncertainty_score":0.9994538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1017192658535194,"score_gpt":0.4076212459539127,"score_spread":0.3059019801003933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}