{"id":"W4322208336","doi":"10.1016/j.isci.2023.106276","title":"An inventory of crosstalk between ubiquitination and other post-translational modifications in orchestrating cellular processes","year":2023,"lang":"en","type":"review","venue":"iScience","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin; SUMO protein; Crosstalk; Acetylation; Cell biology; Biology; NEDD8; Phosphorylation; Ubiquitin-Protein Ligases; Posttranslational modification; Neurodegeneration; Ubiquitin ligase; Computational biology; Chemistry; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004643292,0.0001392055,0.0002557133,0.0001137827,0.0000699671,0.00003472654,0.0002446612,0.0001642757,0.000004028639],"category_scores_gemma":[0.0001597264,0.0001294737,0.00004583293,0.0003412259,0.0001945153,0.00001195014,0.00003881957,0.00009485494,0.000002566479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007814272,"about_ca_system_score_gemma":0.0005351958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002894166,"about_ca_topic_score_gemma":0.00006122349,"domain_scores_codex":[0.9989136,0.00008893741,0.0003367138,0.0003602672,0.0001520541,0.0001483905],"domain_scores_gemma":[0.9994283,0.00003995729,0.0001998034,0.0001855286,0.00009578217,0.00005058797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001197088,0.0002652595,0.004597391,0.04082065,0.00007611556,0.00000558158,0.002314267,0.00007877577,0.1231191,0.002318552,0.00001935013,0.826373],"study_design_scores_gemma":[0.001060074,0.001491666,0.002775845,0.01924413,0.0004189473,0.00004481151,0.0009243787,0.0005104749,0.1262417,0.002807159,0.8415812,0.00289961],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04228875,0.9556205,0.0005887509,0.0000161928,0.00002800407,0.0005823966,0.000395908,0.00001647441,0.0004629997],"genre_scores_gemma":[0.2137274,0.7830534,0.001303365,0.00003600841,0.0003127802,0.0002582031,0.001018454,0.00007168948,0.0002187084],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8415618,"threshold_uncertainty_score":0.5279784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09624937817306027,"score_gpt":0.3618922406009004,"score_spread":0.2656428624278401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}