{"id":"W4322217261","doi":"10.1016/j.intimp.2023.109954","title":"SARS-CoV-2 immune complex triggers human monocyte necroptosis","year":2023,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; Research Manitoba","funders":"Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Instituto Nacional de Ciência e Tecnologia em Tuberculose; University of Manitoba","keywords":"Necroptosis; Monocyte; Immune system; RIPK1; Biology; Syk; Immunology; Programmed cell death; Pathogenesis; Tyrosine kinase; Cell biology; Signal transduction; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006413683,0.000217051,0.0005015904,0.0005230105,0.000215927,0.00003306092,0.0005439473,0.0001143704,0.001487052],"category_scores_gemma":[0.002538272,0.0002033506,0.000303771,0.0005062983,0.0004015188,0.0001034263,0.0006363572,0.0005220195,0.00204541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004121768,"about_ca_system_score_gemma":0.0001587919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004038704,"about_ca_topic_score_gemma":0.000005605454,"domain_scores_codex":[0.9976872,0.000124548,0.0006736857,0.0004352789,0.0005535591,0.0005257724],"domain_scores_gemma":[0.9972278,0.001831387,0.0001482704,0.0002943086,0.0004087094,0.00008952781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007201983,0.000239606,0.001574128,0.00005029325,0.001077159,0.0002528965,0.0001224548,0.00004106011,0.9568216,0.0002612068,0.03481565,0.004023775],"study_design_scores_gemma":[0.01006675,0.0007215444,0.1840208,0.00006849351,0.0002032462,0.00001430876,0.0000624963,0.006386376,0.2695174,0.001068126,0.5275025,0.0003679119],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9525946,0.0001374485,0.00006686844,0.04009243,0.001424807,0.0005415637,0.00004220632,0.0003654503,0.004734561],"genre_scores_gemma":[0.9863502,0.0009902513,0.000125445,0.005260609,0.0003539997,0.0001741949,0.0001860635,0.00003838677,0.006520814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6873041,"threshold_uncertainty_score":0.9994257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1574596458024373,"score_gpt":0.5202321855194182,"score_spread":0.3627725397169809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}