{"id":"W4322486907","doi":"10.1111/his.14896","title":"Lack of reproducibility of histopathological features in <i>MYC</i>‐rearranged large B cell lymphoma using digital whole slide images: a study from the Lunenburg lymphoma biomarker consortium","year":2023,"lang":"en","type":"article","venue":"Histopathology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; BC Cancer Agency","funders":"Barts Charity","keywords":"Lymphoma; Pathology; B-cell lymphoma; Fluorescence in situ hybridization; Medicine; Hematopathology; Diffuse large B-cell lymphoma; H&E stain; Biomarker; Histopathology; Cohort; Oncology; Biology; Immunohistochemistry; Cytogenetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001678966,0.0003571234,0.001150557,0.000244121,0.0001099729,0.00001578724,0.0002809536,0.0002297386,0.00004322981],"category_scores_gemma":[0.001140053,0.0002503831,0.0003099256,0.000695821,0.0005653914,0.00009370292,0.0002955142,0.0001120259,0.0000417414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004582115,"about_ca_system_score_gemma":0.0002581102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009625244,"about_ca_topic_score_gemma":0.0001300315,"domain_scores_codex":[0.996137,0.000514074,0.001004303,0.001411293,0.0004041212,0.0005292461],"domain_scores_gemma":[0.9965825,0.0005452472,0.0004266601,0.002199578,0.0001352457,0.0001107334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009003216,0.009012693,0.9265142,0.00005913679,0.00002993457,0.003231486,0.003192178,0.000002767073,0.05093158,0.00001178257,0.003198339,0.002915558],"study_design_scores_gemma":[0.01093549,0.0006122568,0.9788252,0.00007271599,0.0002577548,0.0002388367,0.001810449,0.00003290064,0.004617343,0.000117921,0.002279015,0.0002001422],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935219,0.002801683,0.00000987456,0.0005114407,0.0003527639,0.001092693,0.00046718,0.00009639638,0.001146061],"genre_scores_gemma":[0.9986913,0.00006066747,0.0001726366,0.0002404309,0.00006323506,0.00009339793,0.000161796,0.00003847251,0.0004780416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05231095,"threshold_uncertainty_score":0.9999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05583996186750207,"score_gpt":0.3174975318966446,"score_spread":0.2616575700291425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}