{"id":"W4322488371","doi":"10.1101/2023.02.27.530167","title":"A generic binding pocket for small molecule <i> I <sub>Ks</sub> </i> activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Volkswagen Foundation; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Activator (genetics); Calmodulin; Biophysics; Protein subunit; Chemistry; Extracellular; Small molecule; Binding site; Stereochemistry; Biology; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549414,0.0002815051,0.0003383647,0.00008406319,0.0002483186,0.0003297422,0.0004460535,0.0002836648,0.00184707],"category_scores_gemma":[0.0001775944,0.0001748623,0.0002626787,0.00006178797,0.0003365517,0.0002589567,0.0003731571,0.0003982383,0.0004485323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004180655,"about_ca_system_score_gemma":0.0002404413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004545102,"about_ca_topic_score_gemma":0.0005102378,"domain_scores_codex":[0.9998922,0.00002073709,0.000006750433,0.00002347905,0.00002762198,0.00002905387],"domain_scores_gemma":[0.9998953,0.00002939369,0.00002893479,0.00001221454,0.000008441447,0.00002559381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003980825,0.00004399408,0.0005830586,0.00009810262,0.00002082899,0.0002399611,0.00006232721,0.00308878,0.9904062,0.002038545,0.0002073978,0.002812725],"study_design_scores_gemma":[0.00019403,0.0004277851,0.003631698,0.00002576356,0.00005620414,0.0009689396,0.0001360351,0.03907691,0.9474204,0.001023461,0.006997624,0.00004113387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826392,0.0006251364,0.01460859,0.0001264403,0.00001590346,0.00004785338,0.00009713262,0.0002001789,0.001639601],"genre_scores_gemma":[0.9965571,0.0001113441,0.002774482,0.00004380017,0.000002549704,0.00001963988,0.00005998037,0.00001069045,0.0004205733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00184707,"threshold_uncertainty_score":0.006179035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548330041051685,"score_gpt":0.2414029473358696,"score_spread":0.2159196469253528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}