{"id":"W4322490033","doi":"10.1038/s41467-023-36590-1","title":"Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre for Antibiotic Resistance Research, University of Gothenburg; Maurice Wilkins Centre for Molecular Biodiscovery; Biomolecular Interaction Centre, University of Canterbury; Stockholms Universitet; Kempestiftelserna; Göteborgs Universitet; Umeå Universitet; Ministero dell’Istruzione, dell’Università e della Ricerca; Knut och Alice Wallenbergs Stiftelse; Australian Cancer Research Foundation; University of Otago; Royal Society Te Apārangi; Ministry of Business, Innovation and Employment; Kempe Foundation; Royal Society; Canterbury Medical Research Foundation; University of Lethbridge; VINNOVA; Australian Nuclear Science and Technology Organisation; Australian Institute of Nuclear Science and Engineering; Science for Life Laboratory; Australian Synchrotron; Marsden Fund; Harvard University","keywords":"Periplasmic space; Transporter; Transport protein; ATP-binding cassette transporter; Biochemistry; Chemistry; Biophysics; Docking (animal); Membrane transport protein; Binding site; Sialic acid; Biology; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358505,0.0001772836,0.0002649207,0.0001738026,0.0004461748,0.0006011532,0.000603659,0.0007031105,0.0006646839],"category_scores_gemma":[0.0001599304,0.0001714517,0.000313311,0.0001519359,0.0003860236,0.0006161615,0.0003745424,0.0004727618,0.0004700646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007250824,"about_ca_system_score_gemma":0.0003143007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006354532,"about_ca_topic_score_gemma":0.0004153961,"domain_scores_codex":[0.9999316,0.000007801787,0.00000547237,0.00001891991,0.00002521937,0.00001095856],"domain_scores_gemma":[0.9998921,0.000008937072,0.00002426815,0.00001089316,0.00001905508,0.00004461051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001321721,0.00006909817,0.001579625,0.0001029235,0.00002409867,0.000843572,0.0001128991,0.002491209,0.9850932,0.006462512,0.0002679469,0.002820749],"study_design_scores_gemma":[0.0001427592,0.0008762634,0.01389657,0.00005720388,0.00005430161,0.002647684,0.0006708131,0.2005779,0.7659283,0.005842143,0.009175011,0.000130945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852704,0.0003630562,0.01308706,0.0002439332,0.00001945778,0.00001553003,0.00005480158,0.0001837174,0.000762049],"genre_scores_gemma":[0.9937555,0.0001933153,0.004884433,0.00005074952,0.000004622341,0.00000995166,0.0001406172,0.00001442646,0.0009463963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007250824,"threshold_uncertainty_score":0.005260825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086093224211826,"score_gpt":0.2584791863051148,"score_spread":0.2476182540629965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}