{"id":"W4322493480","doi":"10.21203/rs.3.rs-2582978/v1","title":"The clinical impact of Lumacaftor-Ivacaftor on structural lung disease and lung function in children aged 6-11 with Cystic Fibrosis in a real-world setting","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Children's Health Foundation; Vertex Pharmaceuticals","keywords":"Ivacaftor; Medicine; Spirometry; Cystic fibrosis; Bronchiectasis; Cohort; Internal medicine; Lung; Airway; Pediatrics; Physical therapy; Surgery; Asthma; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001506061,0.0002608491,0.0003741545,0.0003631491,0.0003844568,0.0007505582,0.0003676658,0.0004494298,0.0009002742],"category_scores_gemma":[0.003682615,0.0001957338,0.0004738482,0.0004372736,0.0004829593,0.0004194826,0.0005254663,0.0005804551,0.000170003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007201796,"about_ca_system_score_gemma":0.0004212021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008970266,"about_ca_topic_score_gemma":0.01069392,"domain_scores_codex":[0.9988698,0.0004908083,0.00007373017,0.0001992331,0.0001906203,0.0001758043],"domain_scores_gemma":[0.9966815,0.0005846545,0.001739549,0.0001481957,0.0002935215,0.0005525916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004137477,0.00008690905,0.9981217,0.0000160817,0.0000301606,0.00007419234,0.00008906588,0.00002450751,0.000133849,0.000003436467,0.00005919085,0.0009470766],"study_design_scores_gemma":[0.00001419119,0.0006016798,0.9989271,0.000005855563,0.00001517189,0.0001453494,0.0001450847,0.00003698649,0.00004199357,0.00000189058,0.00006248031,0.000002249775],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996054,0.0001202248,0.000009204119,0.00001778375,0.000001781698,0.000006118846,0.000140433,8.735105e-7,0.00009821801],"genre_scores_gemma":[0.9996709,0.00005786682,0.00003748586,0.00001450411,0.000004190687,0.000007395778,0.0001544565,5.757342e-7,0.00005268748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008970266,"threshold_uncertainty_score":0.01783609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04524235159289168,"score_gpt":0.4516718517447987,"score_spread":0.406429500151907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}