{"id":"W4322494886","doi":"10.1038/s41587-023-01687-x","title":"Deconvolution of clinical variance in CAR-T cell pharmacology and response","year":2023,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Hatch (Canada)","funders":"","keywords":"Chimeric antigen receptor; Effector; Immunophenotyping; Cytotoxic T cell; T cell; Antigen; Computational biology; Biology; Immunology; Neuroscience; Immune system; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001661406,0.00009708235,0.0004036421,0.0006464857,0.00001908754,0.000001753014,0.0001354462,0.001916929,0.0002354218],"category_scores_gemma":[0.0007628975,0.000090452,0.00005805353,0.0009724346,0.0003964842,0.00001988237,0.0001319798,0.001828992,0.00003098954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006449301,"about_ca_system_score_gemma":0.0001994604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002257103,"about_ca_topic_score_gemma":0.00002204711,"domain_scores_codex":[0.998603,0.0002358533,0.00036446,0.0003576792,0.0001411811,0.0002978337],"domain_scores_gemma":[0.998912,0.0005903845,0.000079913,0.0002902575,0.00006481732,0.00006261302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00472238,0.0001163107,0.01551813,0.00005636876,0.00003031922,0.0002161047,0.00004890139,0.000001019284,0.9529292,0.0003354051,0.00292877,0.02309707],"study_design_scores_gemma":[0.00732679,0.001524639,0.250641,0.00004309014,0.00004202712,0.0001203806,0.0001492461,0.001062602,0.5945458,0.0005091453,0.1438779,0.000157377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853445,0.001692331,0.00001433088,0.01168755,0.0004282321,0.000351195,0.000007729,0.0001310018,0.0003431394],"genre_scores_gemma":[0.9949739,0.002125079,0.0004057094,0.0003460542,0.00009237803,0.00001497246,0.000006876925,0.00001634773,0.002018689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3583834,"threshold_uncertainty_score":0.9993788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02876968778781658,"score_gpt":0.4153753106309904,"score_spread":0.3866056228431738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}