{"id":"W4322495844","doi":"10.1038/s41467-023-36772-x","title":"Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; National Heart, Lung, and Blood Institute; CIHR Skin Research Training Centre; McGill University; National Institute of Allergy and Infectious Diseases; Delaney AIDS Research Enterprise; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Phenotype; Genome; Biology; Genetics; Human immunodeficiency virus (HIV); Genetically engineered; Gene; Computational biology; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021978,0.0001071005,0.000163374,0.0001823171,0.0001292766,0.0002753521,0.0001508696,0.0001934183,0.000796232],"category_scores_gemma":[0.0001823214,0.00008002205,0.0001094722,0.000114539,0.0001260353,0.0001411871,0.0001792181,0.0002918945,0.0002118429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009169235,"about_ca_system_score_gemma":0.00008160737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002834239,"about_ca_topic_score_gemma":0.0003159263,"domain_scores_codex":[0.9999129,0.00001098576,0.000006105384,0.0000239233,0.00002482825,0.00002133506],"domain_scores_gemma":[0.9998689,0.00003070169,0.00002216974,0.00002396956,0.00001599306,0.00003829846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005430185,0.00001714661,0.00249978,0.000008721719,0.000002430666,0.00005227984,0.00004061358,0.00007111129,0.9951901,0.00004321851,0.000007893541,0.00201237],"study_design_scores_gemma":[0.00001653722,0.001022036,0.05790258,0.000007182671,0.00003492553,0.001779422,0.0001814303,0.003261448,0.9345453,0.0001584502,0.001078758,0.00001195211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980966,0.0001069415,0.001248647,0.000009519847,0.000001868989,0.00001220853,0.0001177044,0.00001379156,0.0003926659],"genre_scores_gemma":[0.9970891,0.0000660618,0.001876272,0.00001240711,0.000003598766,0.00002202609,0.0002366146,0.000009995895,0.0006838744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000796232,"threshold_uncertainty_score":0.002663672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02754220681918569,"score_gpt":0.2835150330589651,"score_spread":0.2559728262397794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}