{"id":"W4322496347","doi":"10.15252/embj.2021110496","title":"The eukaryotic translation initiation factor eIF4E reprograms alternative splicing","year":2023,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; National Institutes of Health; Canada Research Chairs; Leukemia and Lymphoma Society","keywords":"Spliceosome; RNA splicing; Biology; Splicing factor; EIF4E; Alternative splicing; Genetics; RNA-binding protein; Translation (biology); Mutation; Polypyrimidine tract; Eukaryotic translation; Initiation factor; Eukaryotic initiation factor; Cell biology; RNA; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008340955,0.00007791357,0.00005954053,0.00003322772,0.0006252559,0.0001529346,0.0002560683,0.00003471906,0.0000100316],"category_scores_gemma":[0.0001538245,0.0000422966,0.0000822367,0.0001502034,0.00005811589,0.000008456911,0.00004183286,0.000235219,0.00003167987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001658509,"about_ca_system_score_gemma":0.00005306237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001504113,"about_ca_topic_score_gemma":0.0000292589,"domain_scores_codex":[0.9990254,0.0001637934,0.0001745215,0.0001190967,0.0002420667,0.0002751063],"domain_scores_gemma":[0.9994886,0.00007693894,0.0000898309,0.0001972161,0.0000826769,0.00006472594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002417973,0.00002483461,0.003574892,0.000009405094,0.0002001889,0.00003089285,0.001149855,0.001321997,0.7148256,0.0002399704,0.002308945,0.2760716],"study_design_scores_gemma":[0.006627952,0.003112923,0.213816,0.000317076,0.0001698171,0.001726916,0.009821494,0.102234,0.5676631,0.01723243,0.07577258,0.001505769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949401,0.0004016171,0.001810102,0.001903146,0.0002085699,0.0001388488,0.000002654131,0.00001332074,0.0005816215],"genre_scores_gemma":[0.9972325,0.001012563,0.00004732591,0.00008845455,0.0006483477,0.00000796894,0.00001488891,0.00001388357,0.0009340649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2745658,"threshold_uncertainty_score":0.4809026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04794691385497064,"score_gpt":0.3286602608829256,"score_spread":0.280713347027955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}