{"id":"W4322496347","doi":"10.15252/embj.2021110496","title":"The eukaryotic translation initiation factor eIF4E reprograms alternative splicing","year":2023,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; National Institutes of Health; Canada Research Chairs; Leukemia and Lymphoma Society","keywords":"Spliceosome; RNA splicing; Biology; Splicing factor; EIF4E; Alternative splicing; Genetics; RNA-binding protein; Translation (biology); Mutation; Polypyrimidine tract; Eukaryotic translation; Initiation factor; Eukaryotic initiation factor; Cell biology; RNA; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000502735,0.0004771993,0.000361089,0.0005045506,0.0002500706,0.0006243605,0.0002118947,0.0004751445,0.001308567],"category_scores_gemma":[0.0004837139,0.0003122351,0.0004888335,0.0003088576,0.0003928122,0.0003464945,0.0006027443,0.0008979929,0.0008130523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003611463,"about_ca_system_score_gemma":0.0002314427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001646911,"about_ca_topic_score_gemma":0.0002919153,"domain_scores_codex":[0.9997497,0.00004788829,0.00002303908,0.00005644255,0.00007205494,0.00005082919],"domain_scores_gemma":[0.9997377,0.00007195635,0.00004581324,0.00004544506,0.00004822014,0.00005084982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003456896,0.00002526259,0.0003287765,0.00005993451,0.00001163946,0.0002084917,0.00002102896,0.0001535707,0.9922914,0.0009083091,0.0002890878,0.005356916],"study_design_scores_gemma":[0.00006621597,0.000121793,0.005009659,0.00001359319,0.00001941579,0.0005974409,0.00005350135,0.001234321,0.9806679,0.0009883182,0.01121657,0.00001132359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9538572,0.01143751,0.01878431,0.001926985,0.002398533,0.00004581009,0.0008646848,0.0006356594,0.0100492],"genre_scores_gemma":[0.984673,0.003008119,0.005695771,0.000306877,0.0001722302,0.0000169914,0.0007365745,0.0001733038,0.005217301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308567,"threshold_uncertainty_score":0.004377544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04794691385497064,"score_gpt":0.3286602608829256,"score_spread":0.280713347027955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}