{"id":"W4322500073","doi":"10.3390/bioengineering10030298","title":"Novel, Blended Polymeric Microspheres for the Controlled Release of Methotrexate: Characterization and In Vivo Antifibrotic Studies","year":2023,"lang":"en","type":"article","venue":"Bioengineering","topic":"Wound Healing and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia; Spinal Cord Injury BC","funders":"Faculty of Pharmaceutical Sciences, University of British Columbia; Canadian Institutes of Health Research","keywords":"In vivo; PLGA; Copolymer; Controlled release; Materials science; Lactic acid; In vitro; Drug delivery; Chemistry; Biomedical engineering; Biophysics; Nanotechnology; Polymer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002790529,0.0003648679,0.0002858167,0.0002012926,0.0001240043,0.0002384107,0.0001842613,0.00041453,0.0005411748],"category_scores_gemma":[0.0002850254,0.0001494132,0.0002256152,0.0001439112,0.0001584785,0.0003040087,0.0001119016,0.0002927682,0.0002321439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716877,"about_ca_system_score_gemma":0.0001637132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004990529,"about_ca_topic_score_gemma":0.0006585863,"domain_scores_codex":[0.999836,0.00002172023,0.00001644656,0.0000455711,0.00005356034,0.00002677344],"domain_scores_gemma":[0.9998288,0.00002906217,0.00007013539,0.00001252702,0.0000338723,0.00002562728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007149525,0.00001880656,0.00005215144,0.00003004772,0.000003111812,0.00002747514,0.000009188856,0.00006351987,0.9981107,0.00003882636,0.00001456655,0.001560136],"study_design_scores_gemma":[0.00002509365,0.000560377,0.001139931,0.000003878241,0.00001694213,0.0001424473,0.000006350463,0.0008411076,0.9956275,0.00001425142,0.001614601,0.000007519601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640017,0.005325179,0.02870665,0.0000817409,0.00005585169,0.0001691201,0.0003354773,0.0001965654,0.001127745],"genre_scores_gemma":[0.977527,0.001258357,0.01900472,0.00003368864,0.00001987402,0.0001323421,0.0002278456,0.00004910329,0.001747003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005411748,"threshold_uncertainty_score":0.001971304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03936577628169963,"score_gpt":0.3153038858798362,"score_spread":0.2759381095981366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}