{"id":"W4322500140","doi":"10.1002/ana.26620","title":"Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease","year":2023,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute of Neurological Disorders and Stroke; Korea Health Industry Development Institute; National Institute on Aging; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Japan Agency for Medical Research and Development; Fondation Brain Canada; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; Genentech; Fleni; Eisai","keywords":"Cerebrospinal fluid; Atrophy; Pathology; Tau protein; Senile plaques; Neurofibrillary tangle; Pittsburgh compound B; Chemistry; Standardized uptake value; Alzheimer's disease; Amyloid (mycology); Diad; Neurodegeneration; Positron emission tomography; Neuroscience; Medicine; Psychology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003282815,0.000527878,0.0003021093,0.0009189646,0.000257256,0.0003125416,0.0001581463,0.0004209268,0.0008058716],"category_scores_gemma":[0.001031498,0.0001398365,0.0001326146,0.0003348227,0.0002358561,0.0003157724,0.0001920903,0.0002245699,0.0001680594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635535,"about_ca_system_score_gemma":0.0001268213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00179212,"about_ca_topic_score_gemma":0.002506915,"domain_scores_codex":[0.999877,0.00001729148,0.00001681559,0.00004145613,0.00003108298,0.00001637171],"domain_scores_gemma":[0.9996537,0.00005633373,0.0001545289,0.000011455,0.00005667861,0.00006726888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009821354,0.000130535,0.9444002,0.00005108273,0.00008886059,0.0009840517,0.0002122569,0.0001083094,0.0460136,0.00001768351,0.0001930817,0.006818236],"study_design_scores_gemma":[0.00001512951,0.0003272369,0.9948587,0.0000104381,0.00002490165,0.001761973,0.00009732113,0.0001841249,0.002567488,0.00002904728,0.0001196274,0.000003969813],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994164,0.0002588558,0.00006597685,0.000008775998,0.000003126202,0.000004561763,0.00009336902,0.000008536553,0.0001405955],"genre_scores_gemma":[0.9993667,0.0001030251,0.0002625893,0.00001633993,0.000005049388,0.000005443863,0.0001425116,0.000002423977,0.00009596618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179212,"threshold_uncertainty_score":0.003563404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08410146032188841,"score_gpt":0.3679820797474506,"score_spread":0.2838806194255621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}