{"id":"W4322500492","doi":"10.1038/s41467-023-35962-x","title":"Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; AstraZeneca","keywords":"Osimertinib; T790M; Lung cancer; Discontinuation; Medicine; Epidermal growth factor receptor; Oncology; Resistance mutation; Internal medicine; Tyrosine-kinase inhibitor; Cancer research; Chemotherapy; Cancer; Biology; Erlotinib; Gene; Gefitinib; Genetics; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166444,0.0001410977,0.0003514012,0.0002636012,0.0001614534,0.00001346426,0.0004830002,0.0001192115,0.0000341844],"category_scores_gemma":[0.00008561969,0.00009478593,0.00009979749,0.003223615,0.00004486709,0.00005405918,0.0001156399,0.0002136055,0.000004256007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057542,"about_ca_system_score_gemma":0.0002159118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005408294,"about_ca_topic_score_gemma":0.01408839,"domain_scores_codex":[0.9988952,0.00009014892,0.0003314521,0.0002428815,0.0002566999,0.0001836717],"domain_scores_gemma":[0.9975665,0.0003844103,0.0001826082,0.001497229,0.0002963202,0.00007293358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03491687,0.003843277,0.892329,0.0001087634,0.01138686,0.00001142063,0.02366891,0.007749649,0.006764791,0.001295211,0.01282304,0.005102166],"study_design_scores_gemma":[0.0261497,0.00018944,0.9641745,0.0002324626,0.004154035,2.20473e-8,0.0006100552,0.001320026,0.0007871106,0.00004366134,0.002166839,0.0001721532],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889215,0.001442271,0.0001481917,0.005807271,0.0001319952,0.002115698,0.0006149476,0.00006034729,0.0007577795],"genre_scores_gemma":[0.9922981,0.0001770101,0.004208477,0.0005578359,0.00001425724,0.0005960743,0.001699614,0.00002317158,0.0004254483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07184546,"threshold_uncertainty_score":0.7861652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205476890241526,"score_gpt":0.33082742314619,"score_spread":0.3187726542437747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}