{"id":"W4322504359","doi":"10.3390/pharmaceutics15030769","title":"Dual-Labelled Nanoparticles Inform on the Stability of Fluorescent Labels In Vivo","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fondation CHU de Québec; Université Laval","keywords":"Fluorescence; Nanomedicine; In vivo; Nanoparticle; Labelling; Ethylene glycol; Biodistribution; Cyanine; Chemistry; Nanotechnology; Biophysics; Materials science; Combinatorial chemistry; In vitro; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008710175,0.0003597555,0.0002788212,0.0003360731,0.0002170453,0.0006781723,0.0002469417,0.0008915199,0.001154174],"category_scores_gemma":[0.001361095,0.0002514377,0.0002127374,0.0001452411,0.0005929038,0.0007513515,0.0003974241,0.0007696871,0.0004521055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004577987,"about_ca_system_score_gemma":0.0002577185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004847104,"about_ca_topic_score_gemma":0.0004728898,"domain_scores_codex":[0.9996519,0.00008251576,0.00001974754,0.0001112785,0.0000792523,0.00005530255],"domain_scores_gemma":[0.999121,0.0003647223,0.0002038587,0.00007276249,0.0001859844,0.00005160366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001261522,0.000007868008,0.0004758981,0.0000350199,0.000006589156,0.00002477185,0.00003095793,0.00009999473,0.9975092,0.0001259257,0.00002192524,0.001535673],"study_design_scores_gemma":[0.000005371954,0.0001814855,0.002303096,0.000009768739,0.00003070262,0.000149091,0.00003266595,0.001728389,0.9944806,0.0001910636,0.0008775397,0.00001019819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9469454,0.005302101,0.04448376,0.0003378378,0.00006824482,0.0000396017,0.00023016,0.0001582022,0.002434639],"genre_scores_gemma":[0.9822458,0.001257027,0.01332576,0.0001504484,0.00001982021,0.00005392656,0.000244295,0.00007525767,0.002627796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154174,"threshold_uncertainty_score":0.004606426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2288144282196427,"score_gpt":0.4516033087023144,"score_spread":0.2227888804826717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}