{"id":"W4322504383","doi":"10.3390/vaccines11030545","title":"Significance of Conserved Regions in Coronavirus Spike Protein for Developing a Novel Vaccine against SARS-CoV-2 Infection","year":2023,"lang":"en","type":"review","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Mitacs; Research Manitoba","keywords":"Immunogenicity; Coronavirus; Virology; Protein subunit; Biology; Pandemic; Immune system; Spike Protein; Epitope; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Vaccination; Virus; Computational biology; Coronavirus disease 2019 (COVID-19); Antibody; Genetics; Gene; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008126227,0.0006168092,0.002611637,0.001195078,0.00009183169,0.00003344935,0.0003365754,0.0005186582,0.000001498875],"category_scores_gemma":[0.001489683,0.0005166264,0.0006088487,0.002275087,0.00003687401,0.0001060075,0.0001617694,0.0005866051,0.00004940431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004647124,"about_ca_system_score_gemma":0.002262048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387254,"about_ca_topic_score_gemma":0.002546889,"domain_scores_codex":[0.9965453,0.0001230977,0.00149265,0.0008200989,0.000376619,0.000642308],"domain_scores_gemma":[0.9974943,0.0006292178,0.0006533185,0.000700068,0.0004875588,0.00003557736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001526137,0.001059184,0.003652426,0.29029,0.001368037,0.000228126,0.0001887509,9.235443e-7,0.0878174,0.001364854,0.002591583,0.6099126],"study_design_scores_gemma":[0.003116337,0.0002946199,0.000475428,0.03936119,0.0003536885,0.00004469707,0.00001602215,0.00006011784,0.01663659,0.0001280776,0.9389721,0.0005411873],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04551016,0.9353886,0.001683361,0.000401435,0.0004690183,0.01578706,0.0001792038,0.0003719947,0.0002091729],"genre_scores_gemma":[0.0007886713,0.9833104,0.001733326,0.003978149,0.0007622671,0.00847813,0.0002408226,0.0004403271,0.00026791],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9363804,"threshold_uncertainty_score":0.9997286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2802626700281133,"score_gpt":0.4497817528773132,"score_spread":0.1695190828491999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}