{"id":"W4322504383","doi":"10.3390/vaccines11030545","title":"Significance of Conserved Regions in Coronavirus Spike Protein for Developing a Novel Vaccine against SARS-CoV-2 Infection","year":2023,"lang":"en","type":"review","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Mitacs; Research Manitoba","keywords":"Immunogenicity; Coronavirus; Virology; Protein subunit; Biology; Pandemic; Immune system; Spike Protein; Epitope; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Vaccination; Virus; Computational biology; Coronavirus disease 2019 (COVID-19); Antibody; Genetics; Gene; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004199216,0.0005671711,0.0008988321,0.00162774,0.0001714777,0.0007251267,0.0004756695,0.0009808714,0.003372391],"category_scores_gemma":[0.0005204967,0.0001812983,0.000557309,0.001092408,0.0002784658,0.000950629,0.0004102302,0.001601893,0.00154212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004598991,"about_ca_system_score_gemma":0.0008615961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000837552,"about_ca_topic_score_gemma":0.00120688,"domain_scores_codex":[0.9998785,0.00002099896,0.00001891685,0.00002061928,0.00004722338,0.00001363169],"domain_scores_gemma":[0.9998413,0.00007309952,0.00002273506,0.000004504203,0.00004495691,0.0000133197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000894083,0.000103475,0.0001937488,0.02697255,0.0001326237,0.0002073392,0.00007130841,0.0004481513,0.005276254,0.005153042,0.02838605,0.9329661],"study_design_scores_gemma":[0.00001867619,0.0001182861,0.0006410269,0.004051636,0.00012963,0.0007488077,0.00004273115,0.00008619788,0.0007517362,0.001378568,0.9920201,0.00001265168],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000213619,0.9975305,0.0001649314,0.0003609384,0.000268146,0.000009355727,0.00002892276,0.00000869691,0.001414922],"genre_scores_gemma":[0.0008524898,0.99793,0.0002324877,0.0002170241,0.0001021272,0.000008318299,0.00004058767,0.000001304636,0.0006156912],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003372391,"threshold_uncertainty_score":0.01128179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2802626700281133,"score_gpt":0.4497817528773132,"score_spread":0.1695190828491999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}