{"id":"W4322504764","doi":"10.1038/s41598-023-30016-0","title":"E-liquid alters oral epithelial cell function to promote epithelial to mesenchymal transition and invasiveness in preclinical oral squamous cell carcinoma","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Oral Health Pathology and Treatment","field":"Dentistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Jewish General Hospital; Réseau de Recherche en Santé Buccodentaire et Osseuse; Canadian Bureau for International Education; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; McGill University; Helsingin Yliopisto","keywords":"Epithelial–mesenchymal transition; Vimentin; Carcinogenesis; Cancer research; Cell growth; Cell culture; Mesenchymal stem cell; Epithelium; Cell; Biology; Cell biology; Cancer; Pathology; Immunology; Medicine; Metastasis; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002705984,0.0002737212,0.0004145401,0.0004780775,0.0003840002,0.0001193114,0.0001247716,0.0002450241,0.0001067478],"category_scores_gemma":[0.0001236575,0.000258688,0.0001163955,0.001030602,0.0001561095,0.0002212745,0.0001317458,0.0002608205,0.0007548486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001379173,"about_ca_system_score_gemma":0.0002523961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003431401,"about_ca_topic_score_gemma":0.00118024,"domain_scores_codex":[0.9961234,0.0003329022,0.0008964436,0.001405531,0.0005187777,0.0007229216],"domain_scores_gemma":[0.998516,0.00008249288,0.0001925021,0.000641971,0.0001251444,0.0004418929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009479299,0.003602556,0.2157129,0.001521029,0.000046315,0.06790447,0.01786683,0.00433148,0.6454467,0.00007287598,0.0126294,0.02138621],"study_design_scores_gemma":[0.005301756,0.005951586,0.5499462,0.0001632939,0.0002496032,0.001209627,0.0008655929,0.0005473125,0.4190875,0.002627278,0.01273828,0.001311953],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863642,0.00003327068,0.0001775036,0.0004889469,0.01114796,0.001420941,0.00006304329,0.000131703,0.0001723624],"genre_scores_gemma":[0.9963696,0.000001196083,0.0003502151,0.0001781202,0.0001363187,0.000162815,0.000172172,0.00003176969,0.00259781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3342333,"threshold_uncertainty_score":0.9999865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04229110333101538,"score_gpt":0.3250371430897114,"score_spread":0.282746039758696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}