{"id":"W4322505162","doi":"10.1016/j.annonc.2023.02.009","title":"Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic castration-sensitive prostate cancer","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prostate Cancer Canada; St. Thomas Hospital","funders":"Cilag; Janssen Research and Development; BeiGene","keywords":"Medicine; Prostate cancer; Placebo; Androgen deprivation therapy; Hazard ratio; Prostate-specific antigen; Enzalutamide; Antiandrogen; Urology; Internal medicine; Proportional hazards model; Oncology; Cancer; Androgen receptor; Pathology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007175506,0.0003027614,0.0007284262,0.0001968767,0.0002695442,0.0003126343,0.0002223862,0.0001426749,0.0005597875],"category_scores_gemma":[0.0004516332,0.0001595674,0.0005073294,0.0002211946,0.000376458,0.0001952243,0.000197719,0.0005334182,0.00005983455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005376232,"about_ca_system_score_gemma":0.001081086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002899093,"about_ca_topic_score_gemma":0.007759957,"domain_scores_codex":[0.9998133,0.00006643152,0.00001387133,0.0000230213,0.00003897948,0.00004457008],"domain_scores_gemma":[0.999706,0.00004437953,0.00008151396,0.00002447715,0.00002142563,0.000122184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2547368,0.02013004,0.4098699,0.0005065387,0.001836455,0.000650867,0.0004875313,0.004343058,0.2121186,0.0002251446,0.001614727,0.09348048],"study_design_scores_gemma":[0.008890335,0.1226045,0.8553467,0.00001432968,0.00041178,0.0006734813,0.000111029,0.002293519,0.008073506,0.00008316879,0.001465461,0.00003209],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995934,0.0001543508,0.00002847743,0.00001773006,0.000003787916,0.00002943323,0.00003740804,0.000003096118,0.0001322121],"genre_scores_gemma":[0.9993442,0.00008378995,0.0001004664,0.00004433395,0.00001009321,0.000027498,0.0002116257,0.000001051975,0.000176904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002899093,"threshold_uncertainty_score":0.005764484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004883302417665,"score_gpt":0.3997285469205547,"score_spread":0.2992402166787882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}