{"id":"W4322505162","doi":"10.1016/j.annonc.2023.02.009","title":"Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic castration-sensitive prostate cancer","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prostate Cancer Canada; St. Thomas Hospital","funders":"Cilag; Janssen Research and Development; BeiGene","keywords":"Medicine; Prostate cancer; Placebo; Androgen deprivation therapy; Hazard ratio; Prostate-specific antigen; Enzalutamide; Antiandrogen; Urology; Internal medicine; Proportional hazards model; Oncology; Cancer; Androgen receptor; Pathology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006086347,0.0002275704,0.0007952089,0.0002032465,0.00008068481,0.00002311678,0.00004537091,0.00009952715,0.00001738551],"category_scores_gemma":[0.00007466861,0.0001348735,0.00003460057,0.0005072145,0.0003838003,0.0001640984,0.00003535469,0.0002072077,0.000001406134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000868725,"about_ca_system_score_gemma":0.000508074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003708698,"about_ca_topic_score_gemma":0.002038905,"domain_scores_codex":[0.9981356,0.0002084657,0.0004675646,0.0004400722,0.0003349203,0.0004133739],"domain_scores_gemma":[0.9983215,0.0004159071,0.0002943334,0.0001616793,0.000660939,0.0001456037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01386596,0.0004892044,0.9601251,0.00004089925,0.0009488888,0.0002390799,0.00182418,0.00002757879,0.0001974007,0.000004222861,0.00008386373,0.02215359],"study_design_scores_gemma":[0.02095913,0.009686901,0.9667485,0.0001125092,0.00006736233,0.000007392283,0.0007575819,0.0004532024,0.0008479226,0.00003446126,0.0001619814,0.0001629971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944902,0.0005187597,0.00001220135,0.002843267,0.00003320134,0.0019026,0.0001141764,0.00002731377,0.00005826586],"genre_scores_gemma":[0.9909783,0.007731811,0.0003351691,0.0003302805,0.00001787822,0.0001343399,0.0002650879,0.00003613176,0.0001710295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02199059,"threshold_uncertainty_score":0.5499981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004883302417665,"score_gpt":0.3997285469205547,"score_spread":0.2992402166787882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}