{"id":"W4322617305","doi":"10.1177/13524585231151951","title":"Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis","year":2023,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; Jewish General Hospital; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; St. Michael's Hospital; Université de Montréal","funders":"National Health and Medical Research Council; Allergan; EMD Serono; Università di Catania; Eisai; Canadian Institutes of Health Research; Ipsen; Fonds Wetenschappelijk Onderzoek; Koning Boudewijnstichting; Mazandaran University of Medical Sciences; Multiple Sclerosis Australia; Multiple Sclerosis Society; Trish Multiple Sclerosis Research Foundation; Multiple Sclerosis Society of Canada; Vlaamse regering; Amicus Therapeutics; International Progressive MS Alliance; Mylan; National Research Foundation; Novartis Pharma; Fondation Brain Canada; Merck KGaA; Univerzita Karlova v Praze; Bristol-Myers Squibb; University of Melbourne; Celgene; Fondazione Italiana Sclerosi Multipla; Biogen; Grifols; F. Hoffmann-La Roche; Monash University; Dementia Australia; Genesis Pharma; Alexion Pharmaceuticals; National Institute for Health and Care Research; Royal Melbourne Hospital Neuroscience Foundation; Medical Research Council; Teva Pharmaceutical Industries; Bayer HealthCare; Sanofi; Sanofi Genzyme; Universität Basel","keywords":"Medicine; Multiple sclerosis; Hazard ratio; Relapsing remitting; Confidence interval; Proportional hazards model; Internal medicine; Pediatrics; Clinically isolated syndrome; Disease; Physical therapy; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003290049,0.0006508827,0.00149837,0.0008681542,0.0007467179,0.0001938351,0.0004680232,0.000323959,0.00006923443],"category_scores_gemma":[0.007856448,0.0005273058,0.0004872717,0.003124627,0.0006575344,0.0008859516,0.0003836679,0.001558459,0.00002896598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008950401,"about_ca_system_score_gemma":0.0002649964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001550616,"about_ca_topic_score_gemma":0.003070079,"domain_scores_codex":[0.9928379,0.0003634657,0.002261893,0.0009662037,0.002107183,0.001463321],"domain_scores_gemma":[0.9943761,0.00194754,0.001292633,0.0009063096,0.0008208432,0.0006565605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001330658,0.0006259092,0.922059,0.0003035592,0.0002769826,0.00002250294,0.003218211,0.002958947,0.06540251,9.614394e-7,0.0004306883,0.003370063],"study_design_scores_gemma":[0.0094562,0.0005337521,0.9500492,0.005066609,0.00013155,0.00002830806,0.003722953,0.02600906,0.004502044,0.00001134429,0.00002904173,0.0004599811],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963599,0.0002472804,0.0002126824,0.0008286694,0.0004824442,0.001441954,0.0001045603,0.0002328048,0.00008967837],"genre_scores_gemma":[0.9942574,0.002405463,0.002399695,0.00003937748,0.0004952103,0.0001358759,0.00005900798,0.0001500462,0.00005794171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06090047,"threshold_uncertainty_score":0.9997178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1165934781784118,"score_gpt":0.3131029049408966,"score_spread":0.1965094267624848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}