{"id":"W4322617305","doi":"10.1177/13524585231151951","title":"Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis","year":2023,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; Jewish General Hospital; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; St. Michael's Hospital; Université de Montréal","funders":"National Health and Medical Research Council; Allergan; EMD Serono; Università di Catania; Eisai; Canadian Institutes of Health Research; Ipsen; Fonds Wetenschappelijk Onderzoek; Koning Boudewijnstichting; Mazandaran University of Medical Sciences; Multiple Sclerosis Australia; Multiple Sclerosis Society; Trish Multiple Sclerosis Research Foundation; Multiple Sclerosis Society of Canada; Vlaamse regering; Amicus Therapeutics; International Progressive MS Alliance; Mylan; National Research Foundation; Novartis Pharma; Fondation Brain Canada; Merck KGaA; Univerzita Karlova v Praze; Bristol-Myers Squibb; University of Melbourne; Celgene; Fondazione Italiana Sclerosi Multipla; Biogen; Grifols; F. Hoffmann-La Roche; Monash University; Dementia Australia; Genesis Pharma; Alexion Pharmaceuticals; National Institute for Health and Care Research; Royal Melbourne Hospital Neuroscience Foundation; Medical Research Council; Teva Pharmaceutical Industries; Bayer HealthCare; Sanofi; Sanofi Genzyme; Universität Basel","keywords":"Medicine; Multiple sclerosis; Hazard ratio; Relapsing remitting; Confidence interval; Proportional hazards model; Internal medicine; Pediatrics; Clinically isolated syndrome; Disease; Physical therapy; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001145232,0.0003591452,0.0004524008,0.0006155857,0.000320897,0.0005450446,0.0003502469,0.0003838995,0.001780596],"category_scores_gemma":[0.004212921,0.0002622938,0.001067495,0.0006733198,0.0002798105,0.0004456655,0.0006699606,0.0009991546,0.0001763023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002317319,"about_ca_system_score_gemma":0.000289416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002837852,"about_ca_topic_score_gemma":0.004663347,"domain_scores_codex":[0.9994354,0.0002018029,0.00005980149,0.0001056148,0.00008912486,0.0001082919],"domain_scores_gemma":[0.9954893,0.0009359946,0.002635696,0.0002418781,0.0001825012,0.0005146228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006263746,0.00004904917,0.995194,0.00004500919,0.0001652856,0.00005724408,0.00007915633,0.00007534667,0.0001000972,0.00001732111,0.0001101607,0.003480857],"study_design_scores_gemma":[0.000009200084,0.00008250219,0.9994236,0.00001469515,0.00006260761,0.0001134136,0.00004984511,0.0001169026,0.0000231415,0.00004176623,0.00005932755,0.000003042283],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974936,0.001682512,0.00007035076,0.0001633042,0.000009509235,0.000008062566,0.0002309173,0.000005575528,0.0003361039],"genre_scores_gemma":[0.9993699,0.0002861227,0.00005010828,0.00001958359,0.00001763454,0.000003882212,0.0001629741,0.000001422374,0.00008828698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002837852,"threshold_uncertainty_score":0.006056607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1165934781784118,"score_gpt":0.3131029049408966,"score_spread":0.1965094267624848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}