{"id":"W4322617343","doi":"10.1021/acsnano.2c10936","title":"Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles","year":2023,"lang":"en","type":"article","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of British Columbia; University Health Network","funders":"Terry Fox Research Institute; Canada Research Chairs; Government of Canada; Princess Margaret Cancer Foundation; Canada Foundation for Innovation; Canadian Institutes of Health Research; NanoMedicines Innovation Network","keywords":"Endosome; Porphyrin; Small interfering RNA; Endocytosis; Gene knockdown; Cell biology; Biophysics; Chemistry; Transfection; Biology; Biochemistry; Cell; Intracellular; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000837422,0.0001734604,0.0001363474,0.00005158061,0.00009269002,0.00003422203,0.0002436812,0.0001426988,0.00004938325],"category_scores_gemma":[0.0000773862,0.0001622832,0.00008354776,0.0002283839,0.00003074702,0.000009155521,0.0001452386,0.00007367554,0.000604228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001014653,"about_ca_system_score_gemma":0.00004848181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002622589,"about_ca_topic_score_gemma":0.0000104956,"domain_scores_codex":[0.998873,0.00004751691,0.0002028388,0.0003750819,0.0001325824,0.0003689597],"domain_scores_gemma":[0.999365,0.00001251302,0.00006375228,0.000379063,0.00006431562,0.0001153309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001009206,0.00005296924,0.0005873428,0.000006195008,0.0000413564,0.0000164263,0.00002658706,0.000009484352,0.9068252,0.000009434019,0.09020158,0.002122531],"study_design_scores_gemma":[0.0003893088,0.0002728302,0.0003966486,0.00001135905,0.00001015063,0.000008350533,0.00005806642,0.00001181895,0.8944077,0.00002101048,0.1042254,0.0001872822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978032,0.0002443153,0.000007378651,0.0005867769,0.0002236351,0.0001073349,0.00003405692,0.0000744437,0.0009188247],"genre_scores_gemma":[0.9938653,0.0003220675,0.00002238825,0.0004177372,0.0002209769,0.00002960774,0.0002371783,0.00002920601,0.00485559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01402384,"threshold_uncertainty_score":0.776633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009793211558659125,"score_gpt":0.2304585472913128,"score_spread":0.2206653357326537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}