{"id":"W4322617343","doi":"10.1021/acsnano.2c10936","title":"Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles","year":2023,"lang":"en","type":"article","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of British Columbia; University Health Network","funders":"Terry Fox Research Institute; Canada Research Chairs; Government of Canada; Princess Margaret Cancer Foundation; Canada Foundation for Innovation; Canadian Institutes of Health Research; NanoMedicines Innovation Network","keywords":"Endosome; Porphyrin; Small interfering RNA; Endocytosis; Gene knockdown; Cell biology; Biophysics; Chemistry; Transfection; Biology; Biochemistry; Cell; Intracellular; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745423,0.0003845592,0.0002004738,0.0001745458,0.0001116074,0.0002427556,0.0001890862,0.0003520266,0.0006431491],"category_scores_gemma":[0.0001517638,0.0001622428,0.0002572119,0.00009932135,0.0002336711,0.0003193662,0.0003093295,0.0003230328,0.0003540379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003720584,"about_ca_system_score_gemma":0.0002492601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000437076,"about_ca_topic_score_gemma":0.0005093567,"domain_scores_codex":[0.9998708,0.00002287259,0.000009024153,0.0000381237,0.00003608907,0.00002303682],"domain_scores_gemma":[0.9999315,0.00001396984,0.00003151558,0.000007065676,0.000009516851,0.000006511925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000235539,0.000008277608,0.00004218028,0.00003284985,0.00000254526,0.00004235681,0.00001012083,0.0001209155,0.9975857,0.0001007666,0.00002360951,0.002007252],"study_design_scores_gemma":[0.000005105915,0.00008424692,0.0001827641,0.000002315307,0.000004473511,0.00007105372,0.000004615802,0.000595607,0.9980727,0.00002205054,0.0009516997,0.000003158601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9469367,0.00270067,0.0462879,0.0002229038,0.00003415652,0.0001105283,0.0001548845,0.0004148148,0.003137348],"genre_scores_gemma":[0.974243,0.001396173,0.01831343,0.0001368103,0.000009801282,0.0000990157,0.0001068625,0.00006824532,0.005626641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006431491,"threshold_uncertainty_score":0.002699435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009793211558659125,"score_gpt":0.2304585472913128,"score_spread":0.2206653357326537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}