{"id":"W4322617490","doi":"10.1073/pnas.2214561120","title":"Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; Embrapa Recursos Genéticos e Biotecnologia; Frederick National Laboratory for Cancer Research; Universitat de Lleida; Universidade Federal do Rio de Janeiro; Generalitat de Catalunya; Ministerio de Ciencia e Innovación; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Institució Catalana de Recerca i Estudis Avançats; Grifols; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Institute of Genetics; National Institutes of Health; U.S. Department of Health and Human Services; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Leidos","keywords":"Glycoprotein; Virology; Biology; Coronavirus; Viral entry; In vitro; Lectin; In vivo; Receptor; Microbiology; Virus; Molecular biology; Viral replication; Coronavirus disease 2019 (COVID-19); Biochemistry; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007029696,0.0002676535,0.0002574855,0.0001157525,0.0001264862,0.0001334418,0.0002044642,0.0002029885,0.0007863494],"category_scores_gemma":[0.0001335515,0.00008649981,0.0001348996,0.00008095521,0.0001497004,0.0001126231,0.0001266463,0.0003010684,0.0001298742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940216,"about_ca_system_score_gemma":0.0002648427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001756767,"about_ca_topic_score_gemma":0.002315407,"domain_scores_codex":[0.999909,0.00001897985,0.000004382697,0.00001268359,0.00002021192,0.00003458144],"domain_scores_gemma":[0.9999382,0.00001320902,0.00001141294,0.000005530929,0.000007464521,0.00002403851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005640466,0.0001445343,0.0003844337,0.00003457545,0.000008648199,0.00002685033,0.00001086235,0.0001733908,0.9963596,0.00005268587,0.00008228519,0.002157921],"study_design_scores_gemma":[0.0001130129,0.002702107,0.00985554,0.000008639848,0.00001786031,0.0002438304,0.00001979917,0.001931422,0.9832774,0.00003194816,0.001792141,0.000006402527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973879,0.0007544861,0.0006374618,0.00004481453,0.00001713733,0.00001921299,0.00006758086,0.0000303713,0.001040931],"genre_scores_gemma":[0.9983633,0.0002879247,0.0004174389,0.00003275507,0.000006561367,0.00001197101,0.000162225,0.000004782911,0.0007130341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756767,"threshold_uncertainty_score":0.00349313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06713845215710479,"score_gpt":0.3713663879491108,"score_spread":0.304227935792006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}