{"id":"W4322617878","doi":"10.1021/acsabm.2c00978","title":"Transfection Efficacy and Cellular Uptake of Lipid-Modified Polyethyleneimine Derivatives for Anionic Nanoparticles as Gene Delivery Vectors","year":2023,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Transfection; Gene delivery; Polyethylenimine; Chemistry; Reporter gene; Conjugated system; Biophysics; Conjugate; Biochemistry; Molecular biology; Polymer; Gene expression; Organic chemistry; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004494829,0.0003577991,0.0002418159,0.0002036933,0.00009907995,0.0003036816,0.0002318563,0.0002656757,0.0004034739],"category_scores_gemma":[0.0003099872,0.0001615378,0.0001979021,0.0001962114,0.0001822587,0.0002649111,0.0001671131,0.0002567094,0.0002174366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003809206,"about_ca_system_score_gemma":0.0001919403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005180649,"about_ca_topic_score_gemma":0.0005136335,"domain_scores_codex":[0.9997721,0.00004996112,0.00002752671,0.00004731352,0.0000724346,0.00003064995],"domain_scores_gemma":[0.9998485,0.00004196633,0.00003852039,0.0000109052,0.00004365798,0.00001646381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002508636,0.00001069804,0.00004898138,0.00001868868,0.000001599416,0.00001390155,0.00001280697,0.00004953522,0.9992822,0.0000343145,0.000005675524,0.0004965358],"study_design_scores_gemma":[0.000003329241,0.0001239054,0.0004448394,0.00000178896,0.000006287118,0.00003050834,0.000004389442,0.0007498555,0.998246,0.000007860246,0.0003783101,0.000002973747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934552,0.001015824,0.004652457,0.00003056882,0.00001486068,0.00003951333,0.00008226031,0.00004072343,0.0006686564],"genre_scores_gemma":[0.9894386,0.0008318255,0.006872201,0.00001560503,0.0000056097,0.0000513309,0.0002444544,0.00001921395,0.002521044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005180649,"threshold_uncertainty_score":0.002763748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829213493147864,"score_gpt":0.2512969320923562,"score_spread":0.2330047971608775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}