{"id":"W4322617878","doi":"10.1021/acsabm.2c00978","title":"Transfection Efficacy and Cellular Uptake of Lipid-Modified Polyethyleneimine Derivatives for Anionic Nanoparticles as Gene Delivery Vectors","year":2023,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Transfection; Gene delivery; Polyethylenimine; Chemistry; Reporter gene; Conjugated system; Biophysics; Conjugate; Biochemistry; Molecular biology; Polymer; Gene expression; Organic chemistry; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000233241,0.0001777214,0.000237728,0.0000688196,0.00008197711,0.00003187126,0.000120248,0.00015732,0.0000137303],"category_scores_gemma":[0.00002612412,0.0001645589,0.00004467382,0.0001109846,0.0000879906,0.000005621086,0.00006326164,0.00002343292,0.00001218863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005865706,"about_ca_system_score_gemma":0.00003371143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002642693,"about_ca_topic_score_gemma":0.000004786689,"domain_scores_codex":[0.9989606,0.00002944456,0.0003212857,0.0003523583,0.00008346524,0.0002528055],"domain_scores_gemma":[0.9995644,0.00002588139,0.0000933938,0.0002076942,0.00005792052,0.00005068661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006364957,0.00004620547,0.00001266907,0.00005954042,0.00008238187,6.399966e-7,0.00009902139,0.00002159415,0.9967418,0.0001344454,0.0001980145,0.001967156],"study_design_scores_gemma":[0.000902408,0.0005211204,0.001996648,0.00001389559,0.00003847196,0.000002286778,0.00006908408,0.000003477814,0.9954619,0.0001089156,0.0007041112,0.0001776652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987957,0.0002096818,0.0001456154,0.00004520908,0.000195605,0.0004477506,0.00009827278,0.00003209511,0.00003005581],"genre_scores_gemma":[0.9984313,0.0005899422,0.0001357097,0.00007594367,0.0002234423,0.00009508118,0.0003424267,0.00002799767,0.00007820036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001983979,"threshold_uncertainty_score":0.6710516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829213493147864,"score_gpt":0.2512969320923562,"score_spread":0.2330047971608775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}