{"id":"W4322619011","doi":"10.1016/j.bonr.2023.101668","title":"FLNA-filaminopathy skeletal phenotypes are not due to an osteoblast autonomous loss-of-function","year":2023,"lang":"en","type":"article","venue":"Bone Reports","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Marsden Fund; Royal Society Te Apārangi; Cure Kids; Canadian Institutes of Health Research; Canada Research Chairs; University of Otago","keywords":"FLNA; Conditional gene knockout; Filamin; Phenotype; Biology; Gene knockout; Cell biology; Osteocyte; Osteoblast; Genetics; Gene; Cell; Cytoskeleton; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262785,0.0008142658,0.0002928271,0.0006122307,0.0002536108,0.0002862345,0.0003012946,0.0007564645,0.004816611],"category_scores_gemma":[0.0003060426,0.0001724189,0.0002686229,0.0001517865,0.0007359795,0.0002419854,0.0002738963,0.0005849378,0.0007279575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001779444,"about_ca_system_score_gemma":0.0002003139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005423749,"about_ca_topic_score_gemma":0.001410303,"domain_scores_codex":[0.9997388,0.00001934359,0.00002684019,0.00007773463,0.00009977307,0.00003765075],"domain_scores_gemma":[0.9997063,0.00005854861,0.000131603,0.00002492089,0.00002053337,0.00005808633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001085301,0.00003849169,0.0007356325,0.00006044734,0.00001726589,0.002013607,0.00001849031,0.00009547349,0.995122,0.0002807932,0.00007129314,0.001437858],"study_design_scores_gemma":[0.00008369586,0.0004193719,0.04641869,0.00005081293,0.0001046141,0.02754784,0.0001195568,0.001746564,0.915044,0.0006185314,0.007821464,0.00002494532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891098,0.0007631705,0.005074695,0.0001520862,0.00006093588,0.00003634714,0.0008146921,0.0002594468,0.003728767],"genre_scores_gemma":[0.9926166,0.0003316287,0.002072653,0.00005926872,0.00001539277,0.00003076032,0.0004888726,0.00006525675,0.004319553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004816611,"threshold_uncertainty_score":0.01611322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547491825775175,"score_gpt":0.2676600198405077,"score_spread":0.2521851015827559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}