{"id":"W4322620203","doi":"10.3390/genes14030604","title":"The Developmental Origins of Cancer: A Review of the Genes Expressed in Embryonic Cells with Implications for Tumorigenesis","year":2023,"lang":"en","type":"review","venue":"Genes","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Children's Hospital Foundation; American College Health Foundation; Children's Hospital Foundation","keywords":"Homeobox protein NANOG; Biology; Carcinogenesis; SOX2; Embryonic stem cell; Cancer stem cell; Cellular differentiation; Epithelial–mesenchymal transition; Cancer research; Rex1; Cell biology; Stem cell; Gene; Cancer; Genetics; Induced pluripotent stem cell; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005456468,0.0008184045,0.00115002,0.003317686,0.0004043431,0.001251445,0.0008654671,0.001183456,0.002504357],"category_scores_gemma":[0.0007503761,0.0003282971,0.000715513,0.004559454,0.0009609624,0.001867372,0.0006499831,0.002314209,0.001459215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009841725,"about_ca_system_score_gemma":0.001139496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001628396,"about_ca_topic_score_gemma":0.002152313,"domain_scores_codex":[0.9997112,0.000051895,0.000061044,0.00005670188,0.00008793573,0.0000312413],"domain_scores_gemma":[0.9993898,0.0003008911,0.00007913048,0.00001792217,0.0001503741,0.00006197473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001558232,0.0001195485,0.00152662,0.02359276,0.0001406178,0.001234062,0.0004111797,0.0006489358,0.005966029,0.01035863,0.1119235,0.8439222],"study_design_scores_gemma":[0.000004087276,0.00006493132,0.001903191,0.003109795,0.00006375626,0.002572446,0.0001088995,0.00005656,0.0003787568,0.001821273,0.989894,0.00002225837],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001765699,0.9975507,0.0002175257,0.0005630439,0.0006949605,0.000002550516,0.00002383923,0.000007403764,0.0007634584],"genre_scores_gemma":[0.0005910021,0.9976341,0.0002231009,0.0003550753,0.0006466153,0.000004240123,0.00003568399,0.000002718108,0.0005074217],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003317686,"threshold_uncertainty_score":0.00837791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05189676014288167,"score_gpt":0.3601763869677129,"score_spread":0.3082796268248312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}