{"id":"W4322620203","doi":"10.3390/genes14030604","title":"The Developmental Origins of Cancer: A Review of the Genes Expressed in Embryonic Cells with Implications for Tumorigenesis","year":2023,"lang":"en","type":"review","venue":"Genes","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Children's Hospital Foundation; American College Health Foundation; Children's Hospital Foundation","keywords":"Homeobox protein NANOG; Biology; Carcinogenesis; SOX2; Embryonic stem cell; Cancer stem cell; Cellular differentiation; Epithelial–mesenchymal transition; Cancer research; Rex1; Cell biology; Stem cell; Gene; Cancer; Genetics; Induced pluripotent stem cell; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004017533,0.0002503208,0.0006942152,0.00005584653,0.0001133269,0.00000968559,0.0009252024,0.000123301,0.000003244431],"category_scores_gemma":[0.00004252864,0.0001314564,0.0003290331,0.0004828183,0.0001384529,0.000001689845,0.00027114,0.00007862534,0.000002747407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009962434,"about_ca_system_score_gemma":0.001696021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000998898,"about_ca_topic_score_gemma":0.0005198094,"domain_scores_codex":[0.9983996,0.0001550051,0.0005664588,0.0003827861,0.0001903384,0.0003058622],"domain_scores_gemma":[0.9985657,0.0001211997,0.0004332648,0.0006567033,0.000184568,0.00003855598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003142806,0.00006476371,0.0001980674,0.1344436,0.0005833911,7.143562e-7,0.00001154204,0.0000187061,0.05637406,0.00006349402,0.002267659,0.8059426],"study_design_scores_gemma":[0.0001151421,0.00003787336,0.00004824669,0.01405356,0.0001788625,0.000004151956,0.00001037347,5.91193e-7,0.03527554,0.000004443813,0.9501159,0.000155351],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000718201,0.9961413,0.00001652903,0.0001370827,0.0001016293,0.002178344,0.00067907,0.000004305818,0.00002352847],"genre_scores_gemma":[0.00002275017,0.9963848,0.0001753569,0.00001709656,0.0000699199,0.00228212,0.0001268034,0.00005451273,0.0008666548],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9478482,"threshold_uncertainty_score":0.5360637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05189676014288167,"score_gpt":0.3601763869677129,"score_spread":0.3082796268248312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}