{"id":"W4322621193","doi":"10.1101/2023.02.28.530460","title":"MEMO1 is a Metal Containing Regulator of Iron Homeostasis in Cancer Cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Cancer Agency; University of Saskatchewan; Canadian Light Source","keywords":"Regulator; Motility; Transferrin receptor; Cancer cell; Transferrin; Ferroportin; Biology; Ferritin; Cell biology; Function (biology); Intracellular; Gene; Biochemistry; Chemistry; Cancer; Genetics; Iron homeostasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006486974,0.0002355462,0.0001572495,0.000159744,0.0002372054,0.0002194755,0.0001777546,0.0002269773,0.001383789],"category_scores_gemma":[0.0001053993,0.00008964608,0.0001270151,0.0001180221,0.00009839189,0.0001038016,0.000215247,0.000239558,0.0005220546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668465,"about_ca_system_score_gemma":0.00009261522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002801933,"about_ca_topic_score_gemma":0.0002651094,"domain_scores_codex":[0.9999491,0.000005646417,0.000003276152,0.00001537561,0.00001486192,0.00001170678],"domain_scores_gemma":[0.9999375,0.000008798697,0.00001752064,0.000006363251,0.00001076165,0.00001899906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006045639,0.000007200902,0.0006889754,0.00002427627,0.000002538856,0.00009547814,0.00001174513,0.00002881534,0.9977229,0.00009642541,0.0001483039,0.001112928],"study_design_scores_gemma":[0.00001908868,0.0001303543,0.03475969,0.00001465692,0.00001328218,0.0009620109,0.00008803408,0.002557705,0.9470358,0.0001979462,0.01421428,0.000007046955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907233,0.002963095,0.002637733,0.0001977841,0.0000480686,0.00001952342,0.0008555326,0.0001650098,0.002389898],"genre_scores_gemma":[0.9926886,0.0005055119,0.001387031,0.00006560619,0.0000108859,0.00002681538,0.001622449,0.00001341604,0.003679683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383789,"threshold_uncertainty_score":0.004629195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02278640362029719,"score_gpt":0.2564416604968822,"score_spread":0.233655256876585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}