{"id":"W4322624135","doi":"10.1016/j.tig.2023.01.009","title":"miRNA biogenesis and inherited disorders: clinico-molecular insights","year":2023,"lang":"en","type":"review","venue":"Trends in Genetics","topic":"Congenital Diaphragmatic Hernia Studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Université de Montréal; McGill University; Jewish General Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Fundació la Marató de TV3; Acacia Foundation","keywords":"Drosha; Biology; microRNA; Gene silencing; Genetics; Gene; Argonaute; Germline; Biogenesis; Dicer; Human genetics; Regulation of gene expression; Computational biology; RNA interference; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000802053,0.0008953235,0.001775854,0.001843079,0.0002070185,0.001424468,0.0008197758,0.00125107,0.002971756],"category_scores_gemma":[0.001270148,0.0003167578,0.0005483509,0.001955927,0.0005308365,0.001106207,0.0009114905,0.001622449,0.001302369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005549663,"about_ca_system_score_gemma":0.0011961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006834936,"about_ca_topic_score_gemma":0.001181575,"domain_scores_codex":[0.9997547,0.00004792147,0.00004484135,0.00004778756,0.00008133964,0.00002342959],"domain_scores_gemma":[0.9994166,0.0003731863,0.0000627066,0.00001517079,0.00009015534,0.00004227003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001473629,0.00004527526,0.0005461641,0.01331664,0.0002042427,0.000492604,0.00004903619,0.0004009822,0.002062799,0.003538446,0.02672376,0.9524727],"study_design_scores_gemma":[0.0000475387,0.00008499149,0.002018077,0.005070229,0.0004286574,0.003432313,0.00009669228,0.0002024716,0.0008161179,0.00384089,0.9839218,0.00004030027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007196694,0.9990535,0.0001263942,0.000229599,0.0001495849,0.000001623977,0.00001563141,0.000005563983,0.0003460381],"genre_scores_gemma":[0.0005735015,0.9984725,0.0002053738,0.0001985531,0.0002549431,0.000003741228,0.0000301104,0.000001428224,0.0002598752],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002971756,"threshold_uncertainty_score":0.009941578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1172389316855589,"score_gpt":0.4159890481333393,"score_spread":0.2987501164477803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}