{"id":"W4322626660","doi":"10.21873/anticanres.16241","title":"Homologous Recombination Defects and Mutations in DNA Damage Response (DDR) Genes Besides<i>BRCA1</i>and<i>BRCA2</i>as Breast Cancer Biomarkers for PARP Inhibitors and Other DDR Targeting Therapies","year":2023,"lang":"en","type":"review","venue":"Anticancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"Homologous recombination; DNA repair; Germline mutation; Biology; Germline; BRCA2 Protein; Genetics; Mutation; Cancer research; Somatic cell; Gene; PARP inhibitor; DNA damage; DNA; Poly ADP ribose polymerase; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005727673,0.0003523046,0.000505033,0.001214701,0.0002028999,0.0007203089,0.0003298548,0.0007123327,0.001907863],"category_scores_gemma":[0.0006091398,0.0001054032,0.0004238526,0.001192769,0.0003364535,0.0003458459,0.0003581627,0.0005641373,0.0006969211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004430368,"about_ca_system_score_gemma":0.0002710114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008117511,"about_ca_topic_score_gemma":0.0007132344,"domain_scores_codex":[0.9995211,0.0001018442,0.00004295026,0.00009345302,0.0001837668,0.00005695962],"domain_scores_gemma":[0.9995387,0.00006798116,0.0002305629,0.00002235421,0.00008332904,0.00005714283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.002855457,0.0007255186,0.2438982,0.004713812,0.0005241056,0.01582982,0.0004120918,0.001148653,0.1614049,0.009305699,0.01850024,0.5406815],"study_design_scores_gemma":[0.0001863236,0.002634223,0.4579419,0.001274585,0.0009254788,0.1016389,0.0005840981,0.002123537,0.1155604,0.004836678,0.3121763,0.0001175669],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5052559,0.4446214,0.00903064,0.003095473,0.0008203681,0.0003863722,0.003127234,0.0003689326,0.03329384],"genre_scores_gemma":[0.8983931,0.07690184,0.005714903,0.001459591,0.000355094,0.000164088,0.003204767,0.00004039369,0.01376624],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001907863,"threshold_uncertainty_score":0.006382406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06587705672369334,"score_gpt":0.4070716985199909,"score_spread":0.3411946417962975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}