{"id":"W4322626660","doi":"10.21873/anticanres.16241","title":"Homologous Recombination Defects and Mutations in DNA Damage Response (DDR) Genes Besides<i>BRCA1</i>and<i>BRCA2</i>as Breast Cancer Biomarkers for PARP Inhibitors and Other DDR Targeting Therapies","year":2023,"lang":"en","type":"review","venue":"Anticancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"Homologous recombination; DNA repair; Germline mutation; Biology; Germline; BRCA2 Protein; Genetics; Mutation; Cancer research; Somatic cell; Gene; PARP inhibitor; DNA damage; DNA; Poly ADP ribose polymerase; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002994737,0.0003654883,0.0006440504,0.0004921796,0.0002875194,0.0001340691,0.0002178567,0.0004235451,0.00001390128],"category_scores_gemma":[0.0006216567,0.0003293226,0.0001270343,0.0005477876,0.0004790256,0.00001615,0.000326152,0.0003044796,0.000004918668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001121907,"about_ca_system_score_gemma":0.0005829593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006114703,"about_ca_topic_score_gemma":0.0005459081,"domain_scores_codex":[0.9966432,0.001006344,0.0004692751,0.0009516888,0.0002960557,0.0006333785],"domain_scores_gemma":[0.9984294,0.0007237563,0.0001638023,0.0003393339,0.000202738,0.0001410333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001534648,0.0002186596,0.002107856,0.017129,0.001422066,0.0001034293,0.001228482,0.0000029804,0.1509031,0.0005056803,0.002198263,0.8226459],"study_design_scores_gemma":[0.0049943,0.00244505,0.003128734,0.01732845,0.000851364,0.0003757919,0.00251275,0.0002325862,0.03850061,0.005201942,0.9214331,0.002995325],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2499428,0.7476419,0.00001133801,0.0003197367,0.0001283299,0.001648365,0.0002539272,0.00002904328,0.00002448797],"genre_scores_gemma":[0.02593121,0.97158,0.0002477758,0.00005963523,0.0001625405,0.001347566,0.0001228889,0.0001485176,0.0003998082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9192348,"threshold_uncertainty_score":0.9999159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06587705672369334,"score_gpt":0.4070716985199909,"score_spread":0.3411946417962975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}