{"id":"W4322627429","doi":"10.1136/rmdopen-2022-002676","title":"Benefit of burosumab in adults with X-linked hypophosphataemia (XLH) is maintained with long-term treatment","year":2023,"lang":"en","type":"article","venue":"RMD Open","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Kyowa Kirin International; Ultragenyx Pharmaceutical","keywords":"Medicine; Ambulatory; Renal function; Regimen; Clinical trial; Morning stiffness; Post-hoc analysis; Physical therapy; Internal medicine; Creatinine; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001468417,0.0002305309,0.001075099,0.0001575092,0.0003144338,0.0004420651,0.0002311289,0.0005321007,0.001634632],"category_scores_gemma":[0.002324458,0.00009381574,0.0007832902,0.0002043572,0.0001995411,0.0004526378,0.0003393657,0.0006924833,0.000148679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580079,"about_ca_system_score_gemma":0.0005144115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005651712,"about_ca_topic_score_gemma":0.001699249,"domain_scores_codex":[0.9994978,0.0002155788,0.00006402521,0.00005917356,0.00009033937,0.00007319087],"domain_scores_gemma":[0.9985716,0.0004323588,0.0004942948,0.00006627011,0.0001198981,0.0003156499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2640692,0.007703253,0.2142352,0.002021594,0.002410035,0.0007804741,0.0007202108,0.0009174381,0.03237205,0.0002200267,0.00206083,0.4724897],"study_design_scores_gemma":[0.02607479,0.2671337,0.6914442,0.0006196486,0.002029197,0.001681487,0.000534467,0.0009107562,0.003418677,0.0002638239,0.005848278,0.00004108337],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992237,0.006306109,0.00009543869,0.0002586858,0.00002917502,0.00009363469,0.0001516847,0.00001156778,0.0008166476],"genre_scores_gemma":[0.9978776,0.0009254385,0.0003166793,0.0002484568,0.00004147476,0.00008691183,0.0002136813,0.000001927574,0.0002878796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634632,"threshold_uncertainty_score":0.00776583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287974572156576,"score_gpt":0.3054504413935175,"score_spread":0.2825706956719517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}