{"id":"W4322630906","doi":"10.3390/cells12050757","title":"Elevated Levels of Lamin A Promote HR and NHEJ-Mediated Repair Mechanisms in High-Grade Ovarian Serous Carcinoma Cell Line","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia","keywords":"Lamin; Genome instability; Biology; Cancer research; Carcinogenesis; Serous fluid; Ovarian carcinoma; Ovarian cancer; DNA damage; Serous carcinoma; DNA repair; Neoplastic transformation; Nuclear lamina; Cell biology; Cancer; Gene; Genetics; Transcription factor; DNA; Nuclear protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007314894,0.0001173298,0.0001273207,0.0001724957,0.0001154406,0.0002358701,0.00005799961,0.0001238261,0.00168262],"category_scores_gemma":[0.00007889218,0.00006175275,0.0001427968,0.0001844,0.0001136655,0.000118013,0.0001038655,0.000240271,0.000340447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001254583,"about_ca_system_score_gemma":0.0001085345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009935006,"about_ca_topic_score_gemma":0.001277383,"domain_scores_codex":[0.9999317,0.000009704778,0.000008209417,0.00001193294,0.00002334846,0.00001506627],"domain_scores_gemma":[0.9999132,0.00001786143,0.00001908487,0.0000162364,0.00001291828,0.00002069286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006379531,0.00001831095,0.0007233614,0.00001785451,0.000002672782,0.00005086583,0.00003311901,0.00001895132,0.9985735,0.00003173427,0.00002024058,0.0004455823],"study_design_scores_gemma":[0.00001095773,0.0004785962,0.04598698,0.000006333422,0.0000143216,0.0004388171,0.000183115,0.0005446952,0.9500393,0.00005102521,0.002240829,0.000005022343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966503,0.000778878,0.0009012003,0.0000387924,0.00001050304,0.000009523293,0.0003541074,0.00003654298,0.0012202],"genre_scores_gemma":[0.996177,0.0004192613,0.0006999151,0.00002449429,0.000003658351,0.00001128568,0.0005837717,0.000006231998,0.002074437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00168262,"threshold_uncertainty_score":0.005628884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009327936485044193,"score_gpt":0.2054903348499615,"score_spread":0.1961623983649173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}