{"id":"W4322631767","doi":"10.1186/s41182-023-00502-2","title":"Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents","year":2023,"lang":"en","type":"article","venue":"Tropical Medicine and Health","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Institute of Agriculture and Natural Resources; University of Toyama; Nagasaki University","keywords":"Trypanosoma cruzi; Benznidazole; Coptisine; In vivo; Amastigote; Pharmacology; Cytotoxicity; Melia azedarach; Alkaloid; Palmatine; Traditional medicine; Leishmania; Biology; In vitro; Chemistry; Microbiology; Medicine; Berberine; Biochemistry; Botany; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002453353,0.0001196977,0.00054685,0.0002021204,0.0001316359,0.000004688989,0.00005297242,0.00007389163,0.0001628696],"category_scores_gemma":[0.0003434902,0.0000871348,0.0000302352,0.0003942841,0.0003512788,0.00006606038,0.00005801145,0.0002716984,0.00003102102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003590382,"about_ca_system_score_gemma":0.0002249906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001687534,"about_ca_topic_score_gemma":0.00002173541,"domain_scores_codex":[0.9986823,0.00004625165,0.0003027705,0.0002572533,0.0003419921,0.0003694661],"domain_scores_gemma":[0.9988362,0.0001772553,0.00008555218,0.0001984095,0.00008942155,0.0006132039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004609147,0.0005781803,0.3214529,0.002935519,0.0001786755,0.0001297993,0.0008052327,2.526259e-7,0.5229989,0.02375855,0.03588186,0.0908192],"study_design_scores_gemma":[0.001837792,0.001306741,0.9876529,0.000257073,0.00001988931,0.00008342848,0.0001103515,0.000106843,0.0005928472,0.00009544431,0.007876897,0.00005980562],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9381052,0.001800997,0.00005134925,0.05828801,0.00006430263,0.0004555723,0.00002685089,0.00006522696,0.001142493],"genre_scores_gemma":[0.9896733,0.008782116,0.00008205301,0.0008680124,0.0001924036,0.00001531029,0.00001749913,0.00001072265,0.0003585943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6662,"threshold_uncertainty_score":0.3553254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.158497952246536,"score_gpt":0.4413447124946856,"score_spread":0.2828467602481496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}