{"id":"W4322631767","doi":"10.1186/s41182-023-00502-2","title":"Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents","year":2023,"lang":"en","type":"article","venue":"Tropical Medicine and Health","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Institute of Agriculture and Natural Resources; University of Toyama; Nagasaki University","keywords":"Trypanosoma cruzi; Benznidazole; Coptisine; In vivo; Amastigote; Pharmacology; Cytotoxicity; Melia azedarach; Alkaloid; Palmatine; Traditional medicine; Leishmania; Biology; In vitro; Chemistry; Microbiology; Medicine; Berberine; Biochemistry; Botany; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006804034,0.0005446261,0.0004118222,0.0005352632,0.0002072079,0.0001657297,0.0001478898,0.000199062,0.001596966],"category_scores_gemma":[0.0001126077,0.00007414048,0.0003362866,0.00021157,0.0001846519,0.0002015584,0.0001487458,0.0003063865,0.00021537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001053696,"about_ca_system_score_gemma":0.0002125725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005322967,"about_ca_topic_score_gemma":0.0008858365,"domain_scores_codex":[0.9999536,0.000005831127,0.000004506702,0.000009132903,0.00001728937,0.000009645541],"domain_scores_gemma":[0.999922,0.00001687809,0.00001953264,0.000006827037,0.00001901753,0.00001564894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000349322,0.00009441833,0.0004888892,0.0004044211,0.00002287361,0.0002184659,0.00002892025,0.00007259838,0.9916591,0.00003395366,0.00008176759,0.00654528],"study_design_scores_gemma":[0.0001468166,0.003130081,0.02810044,0.00009682243,0.0002993411,0.001519481,0.00009771387,0.0005291622,0.9591079,0.00009186549,0.006860659,0.00001970988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862934,0.008960553,0.0007500608,0.0001709093,0.00003676788,0.00005405343,0.0004715582,0.00004598669,0.003216677],"genre_scores_gemma":[0.9919441,0.004387331,0.001473581,0.0001369504,0.00005707151,0.00003265106,0.0006809336,0.00001701462,0.001270356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596966,"threshold_uncertainty_score":0.005342364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.158497952246536,"score_gpt":0.4413447124946856,"score_spread":0.2828467602481496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}