{"id":"W4322719408","doi":"10.1017/cjn.2023.30","title":"The Future: Moving from Phenotypically Defined Diseases Toward Pathophysiological Systems","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Epilepsy Society; Eisai; University College London; Jazz Pharmaceuticals; National Institute for Health and Care Research; GW Pharmaceuticals; Zogenix","keywords":"Pathophysiology; Medicine; Neuroscience; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006755773,0.00053219,0.001010043,0.001472791,0.001268586,0.006378452,0.001222805,0.003130744,0.01125557],"category_scores_gemma":[0.007422416,0.0002952171,0.0006174357,0.0007813679,0.008317749,0.01343839,0.003576963,0.0070372,0.002578381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003004512,"about_ca_system_score_gemma":0.003968014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002472,"about_ca_topic_score_gemma":0.002323302,"domain_scores_codex":[0.9984534,0.0007037834,0.0001349522,0.0002262085,0.0003156775,0.0001660025],"domain_scores_gemma":[0.9952643,0.001832834,0.0002961793,0.0006283362,0.001060805,0.0009175594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003007539,0.0001812512,0.008560596,0.002029559,0.0001057839,0.001428697,0.003694833,0.000718065,0.009033362,0.5523604,0.1218455,0.2997412],"study_design_scores_gemma":[0.00003472568,0.0001282679,0.00814651,0.001510496,0.00007819466,0.002683381,0.003433634,0.000788128,0.002022061,0.4919046,0.4891658,0.000104215],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02139305,0.1791303,0.05021227,0.6805923,0.0113042,0.00005452333,0.001012307,0.0009172927,0.05538374],"genre_scores_gemma":[0.3658426,0.3723013,0.07864445,0.1412759,0.01766378,0.0003260633,0.00174407,0.0008017502,0.02139998],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01125557,"threshold_uncertainty_score":0.03765363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666552607121697,"score_gpt":0.2323772540303118,"score_spread":0.2157117279590948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}