{"id":"W4322719559","doi":"10.1186/s13148-023-01444-6","title":"DNA methylation as a potential mediator of the association between indoor air pollution and neurodevelopmental delay in a South African birth cohort","year":2023,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Pacific Centre for Reproductive Medicine; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; Fogarty International Center; National Institutes of Health; Medical Research Council; South African Medical Research Council; National Research Foundation; Bill and Melinda Gates Foundation","keywords":"dNaM; DNA methylation; Mediation; CpG site; Cognition; Pregnancy; Medicine; Epigenetics; Cohort; Toxicant; Methylation; Genetics; Biology; Internal medicine; Psychiatry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009139578,0.0003924836,0.0002790321,0.0004852187,0.0004366566,0.000402317,0.0003516175,0.0003273505,0.002084674],"category_scores_gemma":[0.00241216,0.0002147953,0.0004292287,0.0006139463,0.0002955187,0.0001731461,0.0006589938,0.0004244213,0.00008538998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002769819,"about_ca_system_score_gemma":0.0004411894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01516714,"about_ca_topic_score_gemma":0.01043463,"domain_scores_codex":[0.9996139,0.0001556842,0.00001761491,0.0001087988,0.00003759241,0.00006638022],"domain_scores_gemma":[0.9994277,0.0002505772,0.0001665154,0.00006109226,0.00003872277,0.00005533551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003977865,0.0000350378,0.9904006,0.00004651272,0.0003819414,0.0003018605,0.000483556,0.0002095582,0.00403575,0.0001733066,0.00010213,0.003431904],"study_design_scores_gemma":[0.00002485252,0.00009022762,0.9967716,0.00001935221,0.000290807,0.0001904547,0.0003279187,0.0009391355,0.0008030637,0.0001978902,0.0003388549,0.000005688894],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990218,0.0003296974,0.0002640745,0.00006516896,0.000003501887,0.0000049805,0.0001785731,0.000003403377,0.0001288852],"genre_scores_gemma":[0.999617,0.00007937577,0.0001213489,0.00001108891,0.00000179431,0.000006346983,0.00005801338,0.000001057445,0.0001039883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01516714,"threshold_uncertainty_score":0.03015774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185449417199531,"score_gpt":0.2976649024813338,"score_spread":0.2791199607613807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}