{"id":"W4322719879","doi":"10.1002/cbic.202300068","title":"Oligonucleotides Containing C5‐Propynyl Modified Arabinonucleic Acids: Synthesis, Biophysical and Antisense Properties","year":2023,"lang":"en","type":"article","venue":"ChemBioChem","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Nucleic acid; Oligonucleotide; Nuclease; RNase H; Propynyl; DNA; RNA; Chemistry; RNase P; Locked nucleic acid; Biophysics; Phosphodiester bond; Biochemistry; Duplex (building); Stereochemistry; Molecular biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001482507,0.0003286683,0.0003102014,0.00004971094,0.0001814518,0.00007372345,0.000254072,0.0002565031,0.00001310546],"category_scores_gemma":[0.0002520561,0.0002944712,0.0001280467,0.0001837754,0.0003416694,0.00001003771,0.0003194934,0.0001429601,0.00004900748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001534812,"about_ca_system_score_gemma":0.00005008235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009449059,"about_ca_topic_score_gemma":7.636788e-7,"domain_scores_codex":[0.9984058,0.00002634781,0.0002543549,0.0006498003,0.0001738416,0.0004898972],"domain_scores_gemma":[0.9991477,0.0000264251,0.00008546319,0.0004844533,0.00007073367,0.0001851831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001149226,0.00005074179,0.0007923075,0.0001054925,0.00007798769,0.00001570953,0.000117012,0.000003870104,0.995899,0.00005661785,0.001815301,0.0009510993],"study_design_scores_gemma":[0.0004083336,0.0000898407,0.001322065,0.00006810486,0.0000399967,0.00002515722,0.0005774887,0.0003363915,0.9947317,0.00004056586,0.001949822,0.000410553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966925,0.0005483218,0.00001140943,0.0001990497,0.00008740944,0.0001468543,0.00002040803,0.0001600769,0.002134008],"genre_scores_gemma":[0.9977646,0.0004117137,0.000112693,0.0001221927,0.0002884351,0.00004151598,0.00009180941,0.00006906856,0.001097927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001167257,"threshold_uncertainty_score":0.9999508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01733383058819712,"score_gpt":0.2251984047348911,"score_spread":0.2078645741466939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}