{"id":"W4322721469","doi":"10.1016/j.jcmgh.2023.02.014","title":"Mimicking Tumor Cell Heterogeneity of Colorectal Cancer in a Patient-derived Organoid-Fibroblast Model","year":2023,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; Childhood Cancer Canada; Magistrat der Stadt Wien; Bundesministerium für Bildung und Frauen; European Commission; German Network for Bioinformatics Infrastructure; Österreichische Forschungsförderungsgesellschaft; Österreichischen Akademie der Wissenschaften; Gesellschaft für Forschungsförderung Niederösterreich; Austrian Science Fund; International Max Planck Research School for Advanced Methods in Process and Systems Engineering; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology","keywords":"Organoid; Colorectal cancer; Fibroblast; Cancer research; Tumor heterogeneity; Medicine; Cell; Tumor cells; Cancer; Oncology; Pathology; Biology; Internal medicine; Cell biology; Cell culture; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009623881,0.0001898522,0.0005496161,0.000226474,0.00004290214,0.000004360078,0.00005138745,0.0001190567,0.00002196456],"category_scores_gemma":[0.00001076209,0.0001859976,0.00008619631,0.0001340327,0.0002486514,0.00002519135,0.0001362229,0.0001839138,0.000001674926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002320797,"about_ca_system_score_gemma":0.00006642102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001039548,"about_ca_topic_score_gemma":0.0003614049,"domain_scores_codex":[0.9986829,0.0000938079,0.0003170059,0.0003951724,0.00008390379,0.0004272622],"domain_scores_gemma":[0.9995552,0.00001663612,0.0001071819,0.0001399186,0.00004369229,0.000137374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007747597,0.00008470503,0.1700309,0.000188565,0.00005700492,0.0004784268,0.0002895629,0.0001359908,0.827574,0.00002262726,0.00003280586,0.0003306233],"study_design_scores_gemma":[0.003475869,0.001026469,0.01114119,0.00006877911,0.0001670444,0.000328816,0.0001439873,0.01149063,0.9718859,0.0000699561,0.00006214227,0.0001392407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972945,0.0008335769,0.001095508,0.0003196155,0.00007724418,0.0002704888,0.00003951657,0.00002442872,0.00004512205],"genre_scores_gemma":[0.9981691,0.000533097,0.000452162,0.0007349515,0.000008339798,0.00004081513,0.00003026041,0.0000241544,0.000007090259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1588897,"threshold_uncertainty_score":0.7584763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009612423373388754,"score_gpt":0.2399036478264611,"score_spread":0.2302912244530723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}