{"id":"W4322725185","doi":"10.1021/acs.joc.2c02796","title":"Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA","year":2023,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences","keywords":"Nucleic acid; Kinetics; Chemistry; Oligonucleotide; Stereochemistry; RNA; Phosphonate; DNA; Receptor–ligand kinetics; Nucleotide; Duplex (building); Base pair; Nucleic acid analogue; Dissociation (chemistry); Nucleic acid thermodynamics; Dissociation constant; Nucleic Acid Denaturation; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777429,0.0001972198,0.0001503363,0.00006102299,0.00007465797,0.0001766978,0.0001782972,0.0001471711,0.0004828337],"category_scores_gemma":[0.0002985328,0.0000840927,0.00007695162,0.00007914528,0.000148052,0.0002253876,0.000116615,0.0002660022,0.000109256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001282943,"about_ca_system_score_gemma":0.0001815815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002673375,"about_ca_topic_score_gemma":0.0007372142,"domain_scores_codex":[0.9999156,0.00001481925,0.000007203539,0.00002289011,0.00002658634,0.00001295422],"domain_scores_gemma":[0.9998587,0.00004967107,0.00004247867,0.00001489125,0.00001934152,0.0000149442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003709273,0.00001506203,0.00007912642,0.00002796685,0.000002363563,0.00001803832,0.00001129838,0.0002368473,0.9978023,0.00008643282,0.000007640071,0.001675777],"study_design_scores_gemma":[0.000004055269,0.000199109,0.0004502243,0.00000238387,0.000005304222,0.00002518576,0.000007600614,0.0008800201,0.9976982,0.0000166955,0.0007074442,0.000003667871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943807,0.00079001,0.003862262,0.00002555754,0.00001128221,0.00003318072,0.00005696703,0.00002525964,0.00081484],"genre_scores_gemma":[0.9922174,0.0008353303,0.005851305,0.00002722396,0.000005913033,0.0000365353,0.00006898617,0.00001694973,0.000940211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004828337,"threshold_uncertainty_score":0.001615226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009112428985366778,"score_gpt":0.2292127163123833,"score_spread":0.2201002873270166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}