{"id":"W4322743667","doi":"10.3390/nu15051238","title":"Rationale, Design and Participants Baseline Characteristics of a Crossover Randomized Controlled Trial of the Effect of Replacing SSBs with NSBs versus Water on Glucose Tolerance, Gut Microbiome and Cardiometabolic Risk in Overweight or Obese Adult SSB Consumer: Strategies to Oppose SUGARS with Non-Nutritive Sweeteners or Water (STOP Sugars NOW) Trial and Ectopic Fat Sub-Study","year":2023,"lang":"en","type":"article","venue":"Nutrients","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Government of Canada; Public Health Ontario; Agriculture and Agri-Food Canada; Mount Sinai Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; St. Michael's Hospital","funders":"Institute of Nutrition, Metabolism and Diabetes; Agriculture and Agri-Food Canada; Canadian Institutes of Health Research; Mitacs; Government of Canada; Dairy Farmers of Canada; Canadian Nutrition Society; University of Toronto; Canada Foundation for Innovation","keywords":"Crossover study; Microbiome; Overweight; Randomized controlled trial; Gut microbiome; Medicine; Baseline (sea); Gut flora; Internal medicine; Obesity; Biology; Bioinformatics; Immunology; Placebo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001637505,0.0003337387,0.00218074,0.0003315706,0.0001015631,0.00006836161,0.00009945861,0.0001230057,0.000003139537],"category_scores_gemma":[0.0008225498,0.0001392784,0.0001456943,0.0004487039,0.0003888409,0.00009715808,0.00007169028,0.0001580612,3.21042e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003159145,"about_ca_system_score_gemma":0.00003643149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001778591,"about_ca_topic_score_gemma":0.0001151201,"domain_scores_codex":[0.9967369,0.001142835,0.0009069898,0.000464637,0.000391928,0.0003566806],"domain_scores_gemma":[0.9973248,0.001665626,0.0003548776,0.0002981126,0.0002694224,0.00008713538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9255363,0.0003698794,0.002320322,0.0001216939,0.0005505423,0.0000133896,0.001409556,0.0000263653,0.06944273,0.000001220025,0.00002209467,0.0001859543],"study_design_scores_gemma":[0.6405061,0.005033419,0.0008126957,0.0003047295,0.0008920436,0.000001544837,0.000153689,0.0006085135,0.3515229,0.000007777104,0.000003554301,0.000152972],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914979,0.00003729688,0.00006587339,0.00005082034,0.0001673472,0.008093613,0.00006392368,0.00001960463,0.000003615233],"genre_scores_gemma":[0.9991601,0.0001911529,0.0002034966,0.00001846384,0.00004417628,0.0003170589,0.00002397358,0.0000244556,0.00001711945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2850301,"threshold_uncertainty_score":0.5679609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306383921247025,"score_gpt":0.2678813908128262,"score_spread":0.254817551600356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}