{"id":"W4322743667","doi":"10.3390/nu15051238","title":"Rationale, Design and Participants Baseline Characteristics of a Crossover Randomized Controlled Trial of the Effect of Replacing SSBs with NSBs versus Water on Glucose Tolerance, Gut Microbiome and Cardiometabolic Risk in Overweight or Obese Adult SSB Consumer: Strategies to Oppose SUGARS with Non-Nutritive Sweeteners or Water (STOP Sugars NOW) Trial and Ectopic Fat Sub-Study","year":2023,"lang":"en","type":"article","venue":"Nutrients","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Government of Canada; Public Health Ontario; Agriculture and Agri-Food Canada; Mount Sinai Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; St. Michael's Hospital","funders":"Institute of Nutrition, Metabolism and Diabetes; Agriculture and Agri-Food Canada; Canadian Institutes of Health Research; Mitacs; Government of Canada; Dairy Farmers of Canada; Canadian Nutrition Society; University of Toronto; Canada Foundation for Innovation","keywords":"Crossover study; Microbiome; Overweight; Randomized controlled trial; Gut microbiome; Medicine; Baseline (sea); Gut flora; Internal medicine; Obesity; Biology; Bioinformatics; Immunology; Placebo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06415386,0.006521402,0.007731191,0.001894759,0.002963169,0.003174556,0.003450603,0.00533681,0.03629272],"category_scores_gemma":[0.04626483,0.003086505,0.003800031,0.002487198,0.005629523,0.003539825,0.001539302,0.005773008,0.007199041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003334707,"about_ca_system_score_gemma":0.01315732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001899544,"about_ca_topic_score_gemma":0.003553213,"domain_scores_codex":[0.9632571,0.0256629,0.002748356,0.003428732,0.003210148,0.001692855],"domain_scores_gemma":[0.9821644,0.005909596,0.003435649,0.001804339,0.003481625,0.003204472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8365698,0.01363556,0.00751113,0.0389457,0.005185853,0.00079671,0.0008659338,0.002921454,0.002906618,0.01828168,0.03007359,0.04230593],"study_design_scores_gemma":[0.8365443,0.05735613,0.008823945,0.01018011,0.005539068,0.0003710647,0.0004926223,0.004491964,0.001302488,0.01643443,0.05816148,0.0003024034],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006498021,0.002184476,0.006137224,0.001388764,0.0014447,0.9774545,0.003017391,0.0001175272,0.001757522],"genre_scores_gemma":[0.01035413,0.0004252414,0.008245951,0.001206627,0.0001587132,0.9785621,0.0003759093,0.000009218983,0.0006621227],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06415386,"threshold_uncertainty_score":0.3392821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306383921247025,"score_gpt":0.2678813908128262,"score_spread":0.254817551600356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}