{"id":"W4322752875","doi":"10.33380/2305-2066-2023-12-1-215-226","title":"Simultaneous Determination of Major Molnupiravir Metabolite (β-D-N4-hydroxycytidine) and Favipiravir in Human Plasma by HPLC-MS/MS","year":2023,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Favipiravir; Chromatography; Chemistry; High-performance liquid chromatography; Formic acid; Ammonium formate; Electrospray ionization; Tandem mass spectrometry; Selected reaction monitoring; Triethylamine; Mass spectrometry; Medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006522329,0.0008139694,0.0004105524,0.0008499419,0.0004849827,0.0004328231,0.0003871656,0.00103371,0.0009394819],"category_scores_gemma":[0.0007841181,0.0003558468,0.0003232435,0.0004151784,0.0003440757,0.0002550502,0.0002940026,0.0004674383,0.0005831948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003893581,"about_ca_system_score_gemma":0.0008400833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001370615,"about_ca_topic_score_gemma":0.001941754,"domain_scores_codex":[0.999047,0.0001806271,0.00006580538,0.0003363354,0.000312392,0.00005775718],"domain_scores_gemma":[0.999739,0.0000678821,0.00005714448,0.00001521681,0.00009371483,0.00002710047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007252096,0.0001251745,0.005211654,0.0004232277,0.0001377166,0.0003091281,0.0001125102,0.0004435428,0.9654655,0.0001604653,0.0004480104,0.02643777],"study_design_scores_gemma":[0.0001447416,0.001703523,0.02552221,0.0001075675,0.0002333204,0.005006707,0.0001573389,0.009740351,0.9459707,0.0003451397,0.01097569,0.00009258628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8022027,0.03505086,0.1437643,0.0006297467,0.0004192296,0.001055495,0.003747834,0.002777567,0.01035231],"genre_scores_gemma":[0.8843524,0.007135021,0.1010219,0.0009180597,0.00009758892,0.0008113303,0.001651073,0.00009187656,0.003920657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001370615,"threshold_uncertainty_score":0.00344938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459622847467556,"score_gpt":0.2870625750746341,"score_spread":0.2724663465999585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}