{"id":"W4322752875","doi":"10.33380/2305-2066-2023-12-1-215-226","title":"Simultaneous Determination of Major Molnupiravir Metabolite (β-D-N4-hydroxycytidine) and Favipiravir in Human Plasma by HPLC-MS/MS","year":2023,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Favipiravir; Chromatography; Chemistry; High-performance liquid chromatography; Formic acid; Ammonium formate; Electrospray ionization; Tandem mass spectrometry; Selected reaction monitoring; Triethylamine; Mass spectrometry; Medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004267386,0.0002170568,0.0003322677,0.0002899976,0.00009801152,0.00003372516,0.00008841699,0.0001002893,0.00002214065],"category_scores_gemma":[0.0000894702,0.0002151334,0.00004090632,0.0004251169,0.00008199028,0.000097214,0.0000465077,0.000161138,0.00001864008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007599718,"about_ca_system_score_gemma":0.0001026786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008298138,"about_ca_topic_score_gemma":0.00005713116,"domain_scores_codex":[0.9982859,0.00004012622,0.0006462005,0.0003596381,0.0003908686,0.0002772145],"domain_scores_gemma":[0.9993057,0.00007600634,0.0002236413,0.0001810107,0.0001036086,0.0001100727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002360867,0.000561495,0.01631478,0.0006653262,0.00008124151,0.0002195853,0.004055954,0.0002591831,0.903191,0.001003825,0.002349121,0.07106235],"study_design_scores_gemma":[0.007252865,0.0002571467,0.131484,0.0004406446,0.0002102074,0.00006036096,0.0003847155,0.06363883,0.7487167,0.0002865562,0.04641448,0.0008535063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966719,0.0001054787,0.0004553593,0.0004053354,0.00008180153,0.0005359635,0.00001566619,0.00007496979,0.001653508],"genre_scores_gemma":[0.991769,0.0001579562,0.002213702,0.00006487008,0.00005127041,0.00001276776,0.0006921822,0.00003001747,0.005008251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1544744,"threshold_uncertainty_score":0.8772886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459622847467556,"score_gpt":0.2870625750746341,"score_spread":0.2724663465999585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}