{"id":"W4322754197","doi":"10.1016/j.exphem.2023.02.004","title":"Circulating cell-free mitochondrial DNA as a diagnostic and prognostic biomarker in chronic and late acute graft-versus-host disease in children","year":2023,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; CancerCare Manitoba; BC Children's Hospital; University of British Columbia","funders":"Institute of Cancer Research","keywords":"Mitochondrial DNA; Biomarker; Medicine; Disease; Cell-free fetal DNA; Cell; Host (biology); Graft-versus-host disease; Pathology; Immunology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000903633,0.0002375617,0.0004143813,0.000305007,0.00005696086,0.00001850068,0.00008126758,0.0001330589,0.00005928204],"category_scores_gemma":[0.0001773779,0.0002405388,0.00004416918,0.0003462294,0.0001632549,0.00008987112,0.0001128433,0.0001514487,0.00005839174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268058,"about_ca_system_score_gemma":0.0001079462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001377359,"about_ca_topic_score_gemma":0.00004462491,"domain_scores_codex":[0.9983773,0.00009124525,0.0003980753,0.0005091027,0.0001870605,0.0004372757],"domain_scores_gemma":[0.9989107,0.000546789,0.00006621135,0.0002454872,0.00001042557,0.0002203776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001274635,0.0003648352,0.8616007,0.0005709415,0.0001266031,0.005434591,0.002818138,0.000006226327,0.1265647,0.001036942,0.00008343779,0.0001182683],"study_design_scores_gemma":[0.01960291,0.0004681523,0.9174755,0.0007271843,0.0001704913,0.001185175,0.000444953,0.001879942,0.05748261,0.0001801112,0.000006863232,0.0003761116],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938148,0.004028314,0.000006193218,0.0002725218,0.0002085386,0.00135546,0.00001892114,0.00008632723,0.0002089574],"genre_scores_gemma":[0.9991223,0.0001750052,0.0001366488,0.00004624105,0.0000353609,0.0002702087,0.0001415204,0.00003962768,0.00003303711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06908207,"threshold_uncertainty_score":0.9808887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341841417311027,"score_gpt":0.2938668369784541,"score_spread":0.2804484228053438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}