{"id":"W4322754219","doi":"10.1093/noajnl/vdad018","title":"Phase II multicenter trial combining nivolumab and radiosurgery for NSCLC and RCC brain metastases","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Université de Sherbrooke; McGill University Health Centre; Centre Hospitalier Universitaire de Sherbrooke; Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal; University of Toronto; University Health Network","funders":"Bristol-Myers Squibb","keywords":"Nivolumab; Medicine; Clinical endpoint; Renal cell carcinoma; Radiosurgery; Lung cancer; Internal medicine; Adverse effect; Phases of clinical research; Oncology; Progression-free survival; Urology; Randomized controlled trial; Surgery; Gastroenterology; Clinical trial; Radiation therapy; Immunotherapy; Cancer; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002243499,0.001186355,0.002032557,0.0003038296,0.0003909099,0.000780838,0.0007844701,0.0009832321,0.003697973],"category_scores_gemma":[0.001007655,0.0004698347,0.001219461,0.0002831149,0.0006469431,0.0005059296,0.0003815792,0.00229732,0.0006771194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009348143,"about_ca_system_score_gemma":0.001852117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000971877,"about_ca_topic_score_gemma":0.002319983,"domain_scores_codex":[0.9993941,0.0003666484,0.00003155689,0.00008476594,0.00004368119,0.00007922929],"domain_scores_gemma":[0.9993502,0.0001123209,0.0001520301,0.00004251132,0.00006513397,0.0002777866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9067092,0.02853077,0.003076525,0.0006490487,0.001130286,0.0001186428,0.0001081863,0.001203269,0.02293074,0.000180091,0.002762892,0.03260049],"study_design_scores_gemma":[0.7546,0.236602,0.003404946,0.00003163341,0.0003372463,0.0001206774,0.00003114732,0.0006892219,0.002300775,0.0001205171,0.001748141,0.00001365168],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909333,0.002427687,0.0005114967,0.0005210467,0.0002413212,0.003208158,0.0009558523,0.00007647325,0.001124596],"genre_scores_gemma":[0.9847366,0.001324522,0.00176586,0.0007651387,0.0003300847,0.005426321,0.002750158,0.00002869192,0.002872681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003697973,"threshold_uncertainty_score":0.01237088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03763381721113974,"score_gpt":0.3684158237246569,"score_spread":0.3307820065135172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}