{"id":"W4322757173","doi":"10.26508/lsa.202301928","title":"RAS and PP2A activities converge on epigenetic gene regulation","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Genentech; Biocenter Finland; Turun Yliopisto; Academy of Finland; Jane ja Aatos Erkon Säätiö; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Paulon Säätiö; Merck KGaA; McGill University; Bayer; Ontario Genomics; Genome Canada; Åbo Akademi; Ida Montinin Säätiö; Pfizer; Bristol-Myers Squibb","keywords":"Protein phosphatase 2; Epigenetics; Derepression; Biology; Chromatin; Cell biology; Genetics; Gene; Cancer research; Phosphorylation; Gene expression; Phosphatase; Psychological repression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842062,0.0004474178,0.0002736225,0.0003132298,0.0002126425,0.0004403478,0.0001598613,0.0001770953,0.001498251],"category_scores_gemma":[0.0001340479,0.0001791711,0.0003308087,0.0001746184,0.0002767306,0.0002308393,0.0004230987,0.0002617572,0.0004481137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002574717,"about_ca_system_score_gemma":0.0002636528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003223935,"about_ca_topic_score_gemma":0.0007964407,"domain_scores_codex":[0.9997818,0.00002826637,0.00001400876,0.00005690719,0.00008611286,0.00003280574],"domain_scores_gemma":[0.9999267,0.00001020697,0.00001892693,0.00001329986,0.00001172523,0.00001912937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008264313,0.000008627945,0.0004543073,0.00002980557,0.000008392083,0.00006333744,0.00001200897,0.00007540453,0.9962555,0.0005625103,0.00003430387,0.00241307],"study_design_scores_gemma":[0.000008581921,0.0001080574,0.01421065,0.00000498589,0.00001897298,0.0004965533,0.00002582154,0.0008713265,0.980128,0.0003889605,0.003733164,0.000004952825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703368,0.007730371,0.01124917,0.0002122404,0.00006117111,0.00003322167,0.0003883259,0.000219358,0.009769343],"genre_scores_gemma":[0.9928142,0.001577834,0.002385047,0.0000457952,0.00001874444,0.0000208464,0.0002838161,0.00002282786,0.002830897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001498251,"threshold_uncertainty_score":0.005012155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822563598377255,"score_gpt":0.2798211114977925,"score_spread":0.26159547551402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}