{"id":"W4322757173","doi":"10.26508/lsa.202301928","title":"RAS and PP2A activities converge on epigenetic gene regulation","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Genentech; Biocenter Finland; Turun Yliopisto; Academy of Finland; Jane ja Aatos Erkon Säätiö; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Paulon Säätiö; Merck KGaA; McGill University; Bayer; Ontario Genomics; Genome Canada; Åbo Akademi; Ida Montinin Säätiö; Pfizer; Bristol-Myers Squibb","keywords":"Protein phosphatase 2; Epigenetics; Derepression; Biology; Chromatin; Cell biology; Genetics; Gene; Cancer research; Phosphorylation; Gene expression; Phosphatase; Psychological repression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003938727,0.0001018675,0.00008193576,0.0000565995,0.0002067268,0.0000543415,0.0001648286,0.00006262906,0.00001042256],"category_scores_gemma":[0.0001857395,0.00009981227,0.00002401457,0.0003544268,0.0003138961,0.00001111675,0.00008390144,0.00004302945,0.00004022531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001081984,"about_ca_system_score_gemma":0.00009991619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000427017,"about_ca_topic_score_gemma":0.00000473728,"domain_scores_codex":[0.9989277,0.00002749115,0.0001259189,0.0004156423,0.0002454523,0.0002577983],"domain_scores_gemma":[0.9994677,0.00002061934,0.00006193151,0.0002818011,0.00005131054,0.000116611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001998102,0.000009073922,0.004784568,0.000006363253,0.000003856844,5.797706e-7,0.00004872617,0.0008299044,0.9910326,0.0002825217,0.0001836233,0.002798199],"study_design_scores_gemma":[0.000164976,0.000174784,0.1660879,0.000009641026,0.000003120767,5.08081e-7,0.00003769537,0.001417517,0.8248612,0.0005367695,0.006565399,0.0001404383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997179,0.0007103772,0.0007157504,0.0003264924,0.0002562193,0.000120009,0.000007728536,0.00002307591,0.0006613585],"genre_scores_gemma":[0.9958875,0.001604782,0.0004900405,0.0002257487,0.0001569604,0.00001403421,0.00002442671,0.00001083326,0.001585684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1661714,"threshold_uncertainty_score":0.4070226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822563598377255,"score_gpt":0.2798211114977925,"score_spread":0.26159547551402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}