{"id":"W4322760552","doi":"10.1158/1538-7445.sabcs22-p2-03-08","title":"Abstract P2-03-08: Deconstructing the molecular characteristics of ER+ HER2+ early breast cancer in the POETIC trial using multiplex immunofluorescence and gene expression profiles","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Breast cancer; Cohort; Cancer; Multiplex; Internal medicine; Oncology; Immune system; Gynecology; Gastroenterology; Immunology; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002268977,0.0004020555,0.0008180845,0.0002768581,0.0002520795,0.0008088872,0.0003336902,0.000495132,0.003021171],"category_scores_gemma":[0.0009696208,0.0001911258,0.0003914592,0.0003413639,0.0004468296,0.0004396032,0.0002909944,0.001252973,0.0004470635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004725321,"about_ca_system_score_gemma":0.0006057748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001527874,"about_ca_topic_score_gemma":0.0003557442,"domain_scores_codex":[0.9995951,0.0002132558,0.0000174701,0.00004918501,0.00006938229,0.00005564592],"domain_scores_gemma":[0.9995009,0.0001568407,0.0001185572,0.00006061549,0.00004986071,0.0001133137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6992894,0.01120635,0.09828431,0.0008621986,0.0007128173,0.0001727298,0.0002913797,0.001600658,0.06450702,0.0006048921,0.003781023,0.1186872],"study_design_scores_gemma":[0.176318,0.3505667,0.3772681,0.0001108922,0.002324565,0.001079022,0.0004117216,0.006244378,0.06215513,0.002195381,0.02124154,0.00008449239],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955176,0.001016639,0.0004059478,0.0002669219,0.00003321356,0.0005802718,0.0007792355,0.00002412946,0.001376054],"genre_scores_gemma":[0.9930554,0.0003989595,0.001260005,0.0003570535,0.00009520809,0.001151825,0.001586506,0.00001000502,0.0020851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003021171,"threshold_uncertainty_score":0.01199961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03513155844510781,"score_gpt":0.3607537482476564,"score_spread":0.3256221898025486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}