{"id":"W4322762554","doi":"10.1016/s0140-6736(23)00061-2","title":"Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":333,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Arrien Pharmaceuticals; Pfizer","keywords":"Ulcerative colitis; Placebo; Medicine; Colitis; Double blind; Maintenance therapy; Induction therapy; Internal medicine; Gastroenterology; Alternative medicine; Chemotherapy; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009719072,0.002519985,0.007120623,0.0009538925,0.0009852082,0.001733209,0.001805274,0.004684285,0.007989582],"category_scores_gemma":[0.007371001,0.001626788,0.004325431,0.00110965,0.002068259,0.001981343,0.001019682,0.003164664,0.001130309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009792527,"about_ca_system_score_gemma":0.0021584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006375165,"about_ca_topic_score_gemma":0.001481459,"domain_scores_codex":[0.9954467,0.002719463,0.0004821496,0.0005163607,0.0004245813,0.000410654],"domain_scores_gemma":[0.9955534,0.001369128,0.00113024,0.000542484,0.0004163677,0.0009884452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9810824,0.007274085,0.0002546166,0.0008623711,0.0007446929,0.00002198971,0.00005736935,0.00009687002,0.002199348,0.00005715991,0.0003266901,0.007022473],"study_design_scores_gemma":[0.957432,0.04100667,0.0006123895,0.00003173083,0.0002890364,0.00001442286,0.00000748513,0.00005784356,0.000148555,0.00004045524,0.0003490823,0.00001034997],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9197906,0.01754697,0.003592456,0.001481426,0.001384136,0.04917021,0.003452789,0.0003740056,0.00320746],"genre_scores_gemma":[0.8877819,0.01148524,0.009348254,0.003665563,0.001903324,0.07799782,0.00319804,0.00009161961,0.004528352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009719072,"threshold_uncertainty_score":0.05140001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05001481999630634,"score_gpt":0.3580194801535488,"score_spread":0.3080046601572425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}