{"id":"W4322762554","doi":"10.1016/s0140-6736(23)00061-2","title":"Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":333,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Arrien Pharmaceuticals; Pfizer","keywords":"Ulcerative colitis; Placebo; Medicine; Colitis; Double blind; Maintenance therapy; Induction therapy; Internal medicine; Gastroenterology; Alternative medicine; Chemotherapy; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008231491,0.0001786446,0.000361086,0.00003397166,0.0002281527,0.00004594064,0.0001615836,0.00006884369,0.000009777271],"category_scores_gemma":[0.000213468,0.0001176206,0.0001021885,0.00007834766,0.0001691345,0.000008213347,0.00005018015,0.00008655369,0.00001953593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001636405,"about_ca_system_score_gemma":0.00006576576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006454972,"about_ca_topic_score_gemma":0.0000592798,"domain_scores_codex":[0.9989354,0.0001488711,0.0002018121,0.0002904347,0.0001016008,0.0003218715],"domain_scores_gemma":[0.9992623,0.00010109,0.0001089465,0.0003190333,0.0001530553,0.00005562163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9443173,0.00005625362,0.0001004901,0.00004366271,0.0007269327,0.00002128419,0.0006159527,0.000106713,0.02292526,0.001065989,0.02720627,0.002813828],"study_design_scores_gemma":[0.9567323,0.0004270806,0.001321706,0.00003213754,0.0000921683,0.00001588401,0.000880353,0.0003266451,0.01898039,0.002332137,0.01854923,0.0003099178],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941701,0.0007215561,0.0001002706,0.001493263,0.0002386559,0.002615629,0.0001031134,0.00004414291,0.0005133233],"genre_scores_gemma":[0.9914298,0.002843629,0.00005053233,0.0007585171,0.001340594,0.001900572,0.0001232743,0.00002809791,0.001524993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.012415,"threshold_uncertainty_score":0.4796427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05001481999630634,"score_gpt":0.3580194801535488,"score_spread":0.3080046601572425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}