{"id":"W4322762568","doi":"10.1016/j.molcel.2023.02.005","title":"The winding road toward transcriptional repression","year":2023,"lang":"en","type":"letter","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Enhancer; Psychological repression; Downregulation and upregulation; Cell biology; Regulation of gene expression; Genetics; Transcriptional regulation; Transition (genetics); Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002010171,0.000320641,0.00018908,0.00004527722,0.0002173863,0.0001142328,0.0005976942,0.0007815005,0.00001343029],"category_scores_gemma":[0.00002698752,0.0002620264,0.000335696,0.0000793143,0.00008045263,0.000001271595,0.0001937921,0.0006688235,0.00009083234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003073112,"about_ca_system_score_gemma":0.0001030568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001488313,"about_ca_topic_score_gemma":0.000004994504,"domain_scores_codex":[0.9982116,0.0001068561,0.0003009497,0.0005983218,0.0003252946,0.0004569418],"domain_scores_gemma":[0.9989584,0.00001544445,0.000155344,0.0007576558,0.00006212718,0.00005101279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001046581,0.000009850443,0.00000731253,0.00006930969,0.00007011995,0.0001616002,0.00002709059,0.0001986486,0.4336642,0.00001451028,0.5649892,0.0007776851],"study_design_scores_gemma":[0.0002339227,0.00006939902,0.00005212384,0.00002848896,0.00004781606,0.00001396716,0.00002207304,0.0002960447,0.03217073,0.0002717319,0.9664224,0.0003713534],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2534004,0.01627141,0.01367329,0.6737146,0.007977919,0.002265595,0.0007024631,0.0002980192,0.03169629],"genre_scores_gemma":[0.3126927,0.004536457,0.00224444,0.5246891,0.01218918,0.0004546946,0.01942207,0.001287739,0.1224836],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.4014935,"threshold_uncertainty_score":0.9999832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015587791739852,"score_gpt":0.2170322733261253,"score_spread":0.2068763954087267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}