{"id":"W4322762568","doi":"10.1016/j.molcel.2023.02.005","title":"The winding road toward transcriptional repression","year":2023,"lang":"en","type":"letter","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Enhancer; Psychological repression; Downregulation and upregulation; Cell biology; Regulation of gene expression; Genetics; Transcriptional regulation; Transition (genetics); Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005399256,0.0006294766,0.001240997,0.0005249975,0.003167454,0.00509585,0.001492022,0.02578651,0.005727438],"category_scores_gemma":[0.01448672,0.0005904512,0.0007155553,0.0003449816,0.01204699,0.007285646,0.003250798,0.0390453,0.003901645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003666963,"about_ca_system_score_gemma":0.002279714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001553188,"about_ca_topic_score_gemma":0.002340913,"domain_scores_codex":[0.9970626,0.0008819893,0.0001520144,0.000358326,0.001104653,0.0004403498],"domain_scores_gemma":[0.9938306,0.00392597,0.0002806238,0.0004369979,0.0005739441,0.0009518737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002904425,0.00005729723,0.00036659,0.0001719251,0.00003369828,0.001474534,0.0003218012,0.0002706252,0.002360155,0.1237366,0.83201,0.03890633],"study_design_scores_gemma":[0.0001173572,0.0000519621,0.0003862531,0.0001253921,0.00001258235,0.0006278328,0.0003466795,0.0004620593,0.001377661,0.21525,0.7811968,0.00004526228],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005936079,0.008626144,0.0008589851,0.9644738,0.02097412,0.000007173072,0.00002416619,0.00005849527,0.004383571],"genre_scores_gemma":[0.02236906,0.009082523,0.0009438166,0.8952481,0.05826456,0.00005771001,0.00003154067,0.00006313602,0.01393957],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02578651,"threshold_uncertainty_score":0.02855432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015587791739852,"score_gpt":0.2170322733261253,"score_spread":0.2068763954087267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}