{"id":"W4322765827","doi":"10.1016/j.jaad.2023.02.040","title":"Rapid and sustained improvements in Generalized Pustular Psoriasis Physician Global Assessment scores with spesolimab for treatment of generalized pustular psoriasis flares in the randomized, placebo-controlled Effisayil 1 study","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Medac; Bausch Health; Eisai; Celltrion; XBiotech; InflaRx; Pfizer; Biogen; Incyte; Les Laboratories Pierre Fabre; Regeneron Pharmaceuticals; Mylan; AstraZeneca; Novocure; Valeant Pharmaceuticals International; Springworks Therapeutics; Castle Biosciences; Therakos; Celgene; Sanofi; LEO Pharma; Ortho Dermatologics; Eli Lilly and Company; Samsung; Bristol-Myers Squibb; Boehringer Ingelheim; Amgen; Meiji Seika Pharma","keywords":"Medicine; Generalized pustular psoriasis; Psoriasis; Dermatology; Randomized controlled trial; Placebo; Pustular psoriasis; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001279967,0.0004466912,0.003182773,0.0004486723,0.0001446724,0.00001667594,0.0006024601,0.0001685679,0.000007508675],"category_scores_gemma":[0.0001634714,0.0002289705,0.0006201923,0.000813529,0.0006851617,0.00009811846,0.00009383559,0.0001962249,9.899485e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001673351,"about_ca_system_score_gemma":0.0002003722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003351741,"about_ca_topic_score_gemma":0.00008089356,"domain_scores_codex":[0.9939379,0.003428463,0.001505863,0.0003439415,0.0002155129,0.0005682911],"domain_scores_gemma":[0.9960243,0.001346667,0.00219889,0.0002838622,0.0001076535,0.00003866471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6998847,0.005760753,0.1971587,0.0001653538,0.01921576,0.0002249158,0.006710435,0.000665126,0.0276127,0.001200434,0.000969235,0.04043199],"study_design_scores_gemma":[0.8784429,0.003564851,0.08578562,0.0001004187,0.004375597,0.0004026604,0.01153849,0.0002399239,0.01366689,0.001008494,0.0004589625,0.0004151289],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989588,0.003155534,0.00003595521,0.003335711,0.0002490707,0.003533771,0.00006685554,0.00001156789,0.00002350337],"genre_scores_gemma":[0.9967548,0.002004709,0.0003964866,0.0002418558,0.00006062834,0.0004680441,0.00001463326,0.00002446076,0.00003439121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1785583,"threshold_uncertainty_score":0.9337146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01630509240174297,"score_gpt":0.3020979104907079,"score_spread":0.2857928180889649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}