{"id":"W4322765827","doi":"10.1016/j.jaad.2023.02.040","title":"Rapid and sustained improvements in Generalized Pustular Psoriasis Physician Global Assessment scores with spesolimab for treatment of generalized pustular psoriasis flares in the randomized, placebo-controlled Effisayil 1 study","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Medac; Bausch Health; Eisai; Celltrion; XBiotech; InflaRx; Pfizer; Biogen; Incyte; Les Laboratories Pierre Fabre; Regeneron Pharmaceuticals; Mylan; AstraZeneca; Novocure; Valeant Pharmaceuticals International; Springworks Therapeutics; Castle Biosciences; Therakos; Celgene; Sanofi; LEO Pharma; Ortho Dermatologics; Eli Lilly and Company; Samsung; Bristol-Myers Squibb; Boehringer Ingelheim; Amgen; Meiji Seika Pharma","keywords":"Medicine; Generalized pustular psoriasis; Psoriasis; Dermatology; Randomized controlled trial; Placebo; Pustular psoriasis; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003758324,0.001470316,0.002687757,0.0004593915,0.00035383,0.0008440052,0.000812475,0.001726981,0.004594701],"category_scores_gemma":[0.001815326,0.0006112937,0.002190442,0.0002680222,0.0009037176,0.0009700449,0.0004082999,0.002884911,0.0005894935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000441437,"about_ca_system_score_gemma":0.0009373445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003501851,"about_ca_topic_score_gemma":0.000933634,"domain_scores_codex":[0.9988432,0.0006659115,0.0000825405,0.0001284811,0.0001115996,0.0001683325],"domain_scores_gemma":[0.9989453,0.0002370293,0.0003404386,0.00009072507,0.00008767751,0.0002988289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9427235,0.01160599,0.00131905,0.001170765,0.00125478,0.000085288,0.00008133551,0.0003534231,0.008169011,0.0001368336,0.001270787,0.03182934],"study_design_scores_gemma":[0.9075096,0.08728641,0.003639034,0.00004433549,0.0003578789,0.00005041729,0.00001499496,0.0001587226,0.000472512,0.0000680232,0.0003872197,0.00001089985],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866563,0.006522637,0.0006864575,0.0006966791,0.0003654442,0.002776011,0.0007007561,0.0001501409,0.001445617],"genre_scores_gemma":[0.9884025,0.00322479,0.001480843,0.001115587,0.0004491585,0.002904389,0.0008456463,0.00002607852,0.001550913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004594701,"threshold_uncertainty_score":0.01987618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01630509240174297,"score_gpt":0.3020979104907079,"score_spread":0.2857928180889649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}