{"id":"W4322769123","doi":"10.1158/1538-7445.sabcs22-pd10-07","title":"Abstract PD10-07: PD10-07 Low plasma estradiol, low expression of estrogen responsive genes and TP53 mutations are associated with poor anti-proliferative response to aromatase inhibitors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Estrogen; Aromatase; Internal medicine; Estrogen receptor; Breast cancer; Immunohistochemistry; Estrogen receptor alpha; Medicine; Aromatase inhibitor; Endocrinology; Biology; Oncology; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004768592,0.0002748377,0.0004239565,0.0002507308,0.0001834706,0.0003681038,0.0002610337,0.0003192206,0.004697783],"category_scores_gemma":[0.0004842795,0.0001295609,0.0002913139,0.0002458889,0.0003177002,0.0001422964,0.0001551222,0.0005807705,0.0005422816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00023991,"about_ca_system_score_gemma":0.0002036929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002803488,"about_ca_topic_score_gemma":0.0002872849,"domain_scores_codex":[0.9998276,0.00005749569,0.00001666217,0.00004460593,0.00003013017,0.00002336904],"domain_scores_gemma":[0.9994847,0.0001269477,0.0001850959,0.00003220606,0.00004371866,0.0001274095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.146019,0.002092886,0.7413463,0.0002321461,0.0007284713,0.0005994073,0.00004199133,0.000439879,0.06683789,0.0001609098,0.004731103,0.03677006],"study_design_scores_gemma":[0.005261336,0.02022402,0.9541631,0.00002406275,0.000631396,0.002982116,0.0000853507,0.001509745,0.0102931,0.0002788365,0.004524837,0.00002218485],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973857,0.0003809145,0.0002091155,0.0001305061,0.00002319989,0.00003993541,0.001081723,0.00001475702,0.0007342111],"genre_scores_gemma":[0.9972011,0.00007426118,0.0002302276,0.0001602395,0.00003021788,0.00004274999,0.00147426,0.000006716675,0.0007803039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004697783,"threshold_uncertainty_score":0.0157156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02261956742019334,"score_gpt":0.332846761262597,"score_spread":0.3102271938424037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}