{"id":"W4322769277","doi":"10.1158/1538-7445.sabcs22-p5-07-08","title":"Abstract P5-07-08: Evaluating the risk of cardiotoxicity associated with concurrent trastuzumab emtansine (TDM1) and radiation therapy in patients with early-stage HER2 positive breast cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Cardiotoxicity; Internal medicine; Oncology; Breast cancer; Trastuzumab; Ejection fraction; Trastuzumab emtansine; Radiation therapy; Adjuvant therapy; Cardiology; Heart failure; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005068734,0.0006401788,0.001444076,0.0006184802,0.0002411985,0.0008946003,0.0006492794,0.0008999727,0.00271518],"category_scores_gemma":[0.007341166,0.0003446829,0.002998339,0.0008055366,0.0003465193,0.0006944921,0.0004631885,0.001123906,0.0003458229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008947768,"about_ca_system_score_gemma":0.000794938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005705571,"about_ca_topic_score_gemma":0.001023774,"domain_scores_codex":[0.997288,0.001551744,0.0003236017,0.0003525399,0.0003768779,0.0001072097],"domain_scores_gemma":[0.9925582,0.003166017,0.002616443,0.0002786952,0.000508636,0.0008719423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4399649,0.004007197,0.4478096,0.002471638,0.02296351,0.0004190235,0.0001401025,0.002094158,0.004566845,0.0001214232,0.001709083,0.07373263],"study_design_scores_gemma":[0.03347775,0.2362811,0.695428,0.0003273585,0.02220952,0.001096741,0.0001383291,0.00401986,0.002853283,0.0002892633,0.003792843,0.00008590279],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865962,0.009686925,0.0005232344,0.0002500633,0.00006297627,0.0005316567,0.001174294,0.0000193041,0.001155395],"genre_scores_gemma":[0.9970129,0.0009345541,0.0004413848,0.0001848504,0.000156342,0.000216341,0.0007572784,0.000005384923,0.00029104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005068734,"threshold_uncertainty_score":0.02680635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0851732530163475,"score_gpt":0.440995054008621,"score_spread":0.3558218009922736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}