{"id":"W4322769285","doi":"10.1158/1538-7445.sabcs22-pd9-06","title":"Abstract PD9-06: Histopathological and molecular immune landscape and DNA damage response signatures to predict response to carboplatin and docetaxel in TNT trial TNBC cohort","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shared Health","funders":"","keywords":"Immune system; Docetaxel; Oncology; Carboplatin; Medicine; Triple-negative breast cancer; Internal medicine; Breast cancer; Cancer; Cohort; Cancer research; Immunology; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006060162,0.0002804125,0.0005039993,0.0002238876,0.000331667,0.0007001791,0.0002960432,0.0002380673,0.00242509],"category_scores_gemma":[0.0007446585,0.0001367681,0.000353526,0.0003716596,0.0002340082,0.0002548083,0.0003942761,0.0005595917,0.0004761551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004828389,"about_ca_system_score_gemma":0.0004113096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001417393,"about_ca_topic_score_gemma":0.002796989,"domain_scores_codex":[0.9997597,0.00004956239,0.00002345468,0.00009017168,0.00005054392,0.00002652745],"domain_scores_gemma":[0.9996125,0.00003358266,0.0001086595,0.00004105289,0.00004681944,0.0001573772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04596972,0.0008556146,0.8752241,0.0002618,0.00081846,0.0003387755,0.0001570715,0.001397355,0.03273252,0.0001854528,0.00513863,0.03692062],"study_design_scores_gemma":[0.00164034,0.004219224,0.9784787,0.00003353117,0.0006546251,0.001451736,0.0001100252,0.002825715,0.00412886,0.0004159202,0.006017697,0.00002381418],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949954,0.0005340911,0.0002582685,0.0001108311,0.00001520053,0.0001093205,0.003013534,0.0000115046,0.0009518376],"genre_scores_gemma":[0.9886782,0.0001774047,0.0005298721,0.0001057433,0.00002857332,0.0001495856,0.009328088,0.00001160963,0.0009909308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00242509,"threshold_uncertainty_score":0.008112788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054599805270391,"score_gpt":0.3824131828101365,"score_spread":0.3418671847574326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}